Hawkins Jessie, Hires Christy, Dunne Elizabeth, Keenan Lindsey
Franklin Health Research Center, 1650 Murfreesboro Rd., Suite 156, Franklin, TN, 37067, USA.
Int J Pediatr Adolesc Med. 2022 Jun;9(2):117-124. doi: 10.1016/j.ijpam.2021.10.001. Epub 2021 Oct 9.
Lavender essential oil and tea tree essential oil have become popular ingredients in personal care and household products in recent decades. Questions regarding the safety of these oils in pediatric populations have been raised, proposing a link between these essential oils and endocrine disruption in children, specifically prepubertal gynecomastia. To date, no epidemiological studies have been conducted to evaluate this proposed link.
This is a cross sectional study conducted among parents of children in the United States to identify the prevalence of endocrine disruption in children aged 2-15 years old. This study also evaluates the potential for a relationship between the exposure of lavender essential oil and tea tree essential oil products and endocrine disrupting outcomes.
In 556 children with a mean age of 6.33 (SD = 3.92), prevalence of endocrine disruption was .016 (SD = 0.13). No cases of prepubertal gynecomastia were identified in either group, and prevalence of precocious puberty, delayed puberty, growth hormone deficiency, and hypothyroidism were all consistent with population norms. Total risk of endocrine disorders among those exposed (0.0194) did not differ from the risk of those unexposed (0.0069). The risk ratio was 2.796 (95% CI: 0.352, 22.163, = .458).
Children who were regularly exposed to lavender or tea tree essential oils experienced the same risk of endocrine disorders as those who were not exposed.
近几十年来,薰衣草精油和茶树精油已成为个人护理产品和家居用品中广受欢迎的成分。关于这些精油在儿科人群中的安全性问题引发了关注,有人提出这些精油与儿童内分泌紊乱之间存在联系,特别是青春期前男性乳腺增生。迄今为止,尚未进行流行病学研究来评估这一潜在联系。
这是一项在美国儿童家长中开展的横断面研究,旨在确定2至15岁儿童内分泌紊乱的患病率。本研究还评估了薰衣草精油和茶树精油产品暴露与内分泌干扰结果之间的潜在关系。
在平均年龄为6.33岁(标准差=3.92)的556名儿童中,内分泌紊乱的患病率为0.016(标准差=0.13)。两组均未发现青春期前男性乳腺增生病例,性早熟、青春期延迟、生长激素缺乏和甲状腺功能减退的患病率均与总体标准一致。暴露组内分泌疾病的总风险(0.0194)与未暴露组的风险(0.0069)无差异。风险比为2.796(95%置信区间:0.352,22.163,P=0.458)。
经常接触薰衣草或茶树精油的儿童与未接触者经历内分泌紊乱的风险相同。