Huang Yu, Li Jia, Bian Chao, Li Ruihan, You Xinxin, Shi Qiong
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, BGI, Shenzhen, China.
Department of Plant Biotechnology and Bioinformatics, Ghent University, VIB-Ugent Center for Plant Systems Biology, Ghent, Belgium.
Front Genet. 2022 May 19;13:820442. doi: 10.3389/fgene.2022.820442. eCollection 2022.
As an important hormone, melatonin participates in endocrine regulation of diverse functions in vertebrates. Its biosynthesis is catalyzed by four cascaded enzymes, among them, arylalkylamine -acetyltransferase (AANAT) is the most critical one. Although only single gene has been identified in most groups of vertebrates, researchers including us have determined that fish have the most diverse of genes (, and ), playing various potential roles such as seasonal migration, amphibious aerial vision, and cave or deep-sea adaptation. With the rapid development of genome and transcriptome sequencing, more and more putative sequences of fish genes are going to be available. Related phylogeny and functional investigations will enrich our understanding of AANAT functions in various fish species.
褪黑素作为一种重要的激素，参与脊椎动物多种功能的内分泌调节。其生物合成由四种级联酶催化，其中芳基烷基胺 - 乙酰基转移酶（AANAT）是最关键的一种。尽管在大多数脊椎动物群体中仅鉴定出单个基因，但包括我们在内的研究人员已确定鱼类拥有最为多样的基因（……），发挥着诸如季节性洄游、水陆空视觉以及洞穴或深海适应等各种潜在作用。随着基因组和转录组测序的快速发展，越来越多的鱼类AANAT基因推定序列将会可得。相关的系统发育和功能研究将丰富我们对各种鱼类物种中AANAT功能的理解。
