Syafrita Yuliarni, Amir Darwin, Susanti Restu, Fadhilah I
Neurology Department, Faculty of Medicine, Andalas University, Indonesia.
Hospital, Perintis Kemerdekaan Street, Padang, West Sumatra, Indonesia.
Dement Neuropsychol. 2020 Jan-Mar;14(1):41-46. doi: 10.1590/1980-57642020dn14-010007.
A few studies have shown that serum brain-derived neurotrophic factor (BDNF) level in post-stroke depression is highly correlated with memory and neuropsychiatric disturbances.
This study aimed to elucidate the relationship of serum BDNF, malondialdehyde (MDA), and 8-Hydroxy 2-Deoxyguanosine (8-OhdG) levels in acute stroke cases with one-month post-stroke depression.
An observational study was conducted of 72 post-ischemic stroke patients in the Neurology ward of the Dr. M. Djamil Hospital, Padang, West Sumatra, Indonesia. Acute stroke (< 48 hours) serum BDNF, MDA, and 8-OhdG levels were measured using ELISA. Based on observations using the Hamilton Depression Rating Scale conducted one month after stroke, respondents were divided into two groups: with and without depression. The mean serum level was analyzed using the -test and Mann-Whitney test, while differences in basic characteristics were analyzed using the Chi-square test. Multivariate analysis was conducted to determine the most significant factor associated with post-stroke depression. The error rate was set at 5%.
BDNF levels in acute stroke were significantly lower in the depression group than in the non-depression group (p < 0.05). MDA and 8-OhdG levels in acute stroke were higher in the depression group (p < 0.05). BDNF level during acute stroke was negatively correlated with post-stroke depression, while, conversely, acute stroke MDA and 8-OhdG levels were positively correlated with depression.
BDNF had a negative correlation, while MDA and 8-OhdG had a positive correlation, with depression one-month post-stroke. 8-OhdG was the most influential factor in post-stroke depression.
一些研究表明，中风后抑郁症患者血清脑源性神经营养因子（BDNF）水平与记忆力及神经精神障碍高度相关。
本研究旨在阐明急性中风患者血清BDNF、丙二醛（MDA）和8-羟基-2'-脱氧鸟苷（8-OhdG）水平与中风后1个月抑郁症之间的关系。
在印度尼西亚西苏门答腊省巴东市M. 贾米尔博士医院神经科病房，对72例缺血性中风后患者进行了一项观察性研究。使用酶联免疫吸附测定法（ELISA）测量急性中风（<48小时）患者的血清BDNF、MDA和8-OhdG水平。根据中风后1个月使用汉密尔顿抑郁量表进行的观察，将受访者分为两组：有抑郁症组和无抑郁症组。使用t检验和曼-惠特尼检验分析平均血清水平，使用卡方检验分析基本特征的差异。进行多变量分析以确定与中风后抑郁症相关的最显著因素。错误率设定为5%。
抑郁症组急性中风患者的BDNF水平显著低于非抑郁症组（p<0.05）。抑郁症组急性中风患者的MDA和8-OhdG水平较高（p<0.05）。急性中风期间的BDNF水平与中风后抑郁症呈负相关，相反，急性中风患者的MDA和8-OhdG水平与抑郁症呈正相关。
BDNF与中风后1个月的抑郁症呈负相关，而MDA和8-OhdG与抑郁症呈正相关。8-OhdG是中风后抑郁症最具影响力的因素。
