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急性脑卒中患者同型半胱氨酸水平与脑卒中后抑郁的相关性：系统评价和荟萃分析。

Association between homocysteine levels in acute stroke and poststroke depression: A systematic review and meta-analysis.

机构信息

School of Medicine (School of Nursing), Nantong University, Nantong, Jiangsu, China.

Department of Neurology, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu, China.

出版信息

Brain Behav. 2022 Jun;12(6):e2626. doi: 10.1002/brb3.2626. Epub 2022 May 23.

DOI:10.1002/brb3.2626
PMID:35605010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9226802/
Abstract

BACKGROUND

Homocysteine (Hcy) has been confirmed to be associated with depression, but its relationship with poststroke depression (PSD) remains controversial. So far, there is no meta-analysis of the correlation between Hcy level in acute stroke and PSD.

METHODS

A systematic search of a sub-database of studies reporting the level of Hcy in the acute phase of ischemic stroke and PSD as of November 2021 was performed. Data extraction was performed strictly according to the inclusion and exclusion criteria. All data were analyzed using STATA 11.0. The standardized root mean square difference (SMD) and 95% confidence interval (CI) were used to compare continuous variables.

RESULTS

A total of 11 studies were included in this study, including 2789 participants. The results of this meta-analysis showed that admission the levels of Hcy were significantly higher in PSD survivors, compared to non-PSD survivors (SMD = 0.37, 95%CI = 0.07-0.66, P ＜ .001). Subgroup analysis showed that survivors with PSD diagnosed more than 3 months after stroke had significantly different the levels of from non-PSD survivors (6 months: SMD = 0.61, 95%CI = 0.40-0.82, 9 months: SMD = 1.00, 95%CI = 0.59-1.41).

CONCLUSION

The level of Hcy in the acute phase of ischemic stroke is a risk factor for PSD.

摘要

背景

同型半胱氨酸（Hcy）已被证实与抑郁症有关，但它与卒中后抑郁（PSD）的关系仍存在争议。迄今为止，尚无关于急性卒中患者 Hcy 水平与 PSD 之间相关性的荟萃分析。

方法

对截至 2021 年 11 月报道急性缺血性卒中及 PSD 患者 Hcy 水平的研究子数据库进行系统检索。严格按照纳入和排除标准进行数据提取。所有数据均采用 STATA 11.0 进行分析。采用标准化均方根差（SMD）和 95%置信区间（CI）比较连续变量。

结果

本研究共纳入 11 项研究，共 2789 例患者。荟萃分析结果显示，PSD 幸存者入院时 Hcy 水平明显高于非 PSD 幸存者（SMD=0.37，95%CI=0.07-0.66，P＜0.001）。亚组分析显示，卒中后 3 个月以上诊断为 PSD 的幸存者与非 PSD 幸存者的 Hcy 水平有显著差异（6 个月：SMD=0.61，95%CI=0.40-0.82；9 个月：SMD=1.00，95%CI=0.59-1.41）。

结论

急性缺血性卒中患者 Hcy 水平是 PSD 的危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56bb/9226802/839267671be2/BRB3-12-e2626-g006.jpg
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