Sackeim H, Decina P, Prohovnik I, Malitz S
Arch Gen Psychiatry. 1987 Apr;44(4):355-60. doi: 10.1001/archpsyc.1987.01800160067009.
In a random-assignment trial to unilateral right and bilateral electrode placements, electroconvulsive therapy (ECT) stimulus intensity was titrated to just above seizure threshold for each of 52 depressed patients. Seizure threshold was quantified in units of charge. There was a 12-fold range in the minimum electrical intensity necessary to produce seizure. Sex, age, electrode placement, and the cumulative number of treatments were each associated with seizure threshold. Bilateral ECT had both a higher initial seizure threshold and a greater cumulative increase in seizure threshold compared with unilateral ECT. Clinical and research implications are discussed with respect to dosing strategies in ECT.
在一项针对单侧右侧和双侧电极放置的随机分配试验中，对52名抑郁症患者的每一位，电休克疗法（ECT）的刺激强度被滴定至刚好高于癫痫阈值。癫痫阈值以电荷单位进行量化。产生癫痫所需的最小电强度范围为12倍。性别、年龄、电极放置以及治疗累积次数均与癫痫阈值相关。与单侧ECT相比，双侧ECT既有更高的初始癫痫阈值，癫痫阈值的累积增加也更大。针对ECT中的给药策略讨论了临床和研究意义。
