电休克治疗期间癫痫发作阈值的变化。
Change in seizure threshold during electroconvulsive therapy.
作者信息
Fink Max, Petrides Georgios, Kellner Charles, Mueller Martina, Knapp Rebecca, Husain Mustafa M, Rasmussen Keith, Rummans Teri, O'Connor Kevin
机构信息
Long Island Jewish-Hillside Hospital, Glen Oaks, NY, USA.
出版信息
J ECT. 2008 Jun;24(2):114-6. doi: 10.1097/YCT.0b013e31815f65b9.
UNLABELLED
The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients.
METHODS
In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST.
RESULTS
In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission.
CONCLUSIONS
In a study of bilateral ECT, the ST did not rise conclusively with remission.
未标注
癫痫发作阈值（ST）是诱发全身强直阵挛性发作所需最小电能的一种度量。有人建议对癫痫发作阈值进行剂量滴定，以优化电休克治疗（ECT）中的刺激剂量。在大量单相抑郁症患者样本中研究了癫痫发作阈值随病情缓解的变化。
方法
在一项关于ECT成功后的维持治疗研究中，采用传统的癫痫发作阈值测量方案，在首次治疗时测定癫痫发作阈值，并在病情缓解1周后再次测定。患者采用双侧电极放置，剂量为测得的癫痫发作阈值的150%。
结果
在80名受试者中，70%的人在病情缓解时癫痫发作阈值测量结果相同，21%的人升高，9%的人降低。
结论
在一项双侧ECT研究中，癫痫发作阈值并未随病情缓解而明确升高。
Zotero 插件