Choi Dong Hyeok, Ahn So Hyun, Park Kwangwoo, Choi Sang Hyun, Kim Jin Sung
Department of Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Front Vet Sci. 2022 May 18;9:832272. doi: 10.3389/fvets.2022.832272. eCollection 2022.
The purpose of this study is to propose a technique for delivering accurate doses in an image-guided system by developing an experimental setup optimized for total lymphoid irradiation (TLI) in rat lung transplantation.
In this study, a position-controlled shielding system was developed, and the dose was quantitatively evaluated using a 3D rat phantom and Gafchromic EBT3 film. In addition, we made our own image-guided system that allows the position of the rat and the shielding system to be confirmed during TLI.
As a result of using the position-controlled shielding system, it was found that the doses to the head and lungs were reduced by 93.1 and 87.4%, respectively, of the prescribed doses. In addition, it was shown that the position of the shielding system can be easily confirmed by using the image guidance system.
A shielding apparatus that can control dose delivery according to the size of the rat can optimize the dose for TLI in rat lung transplantation.
本研究的目的是通过开发一种针对大鼠肺移植中全淋巴照射（TLI）优化的实验装置，提出一种在图像引导系统中进行精确剂量输送的技术。
在本研究中，开发了一种位置控制屏蔽系统，并使用三维大鼠模型和Gafchromic EBT3胶片对剂量进行定量评估。此外，我们制作了自己的图像引导系统，该系统能够在TLI过程中确认大鼠和屏蔽系统的位置。
使用位置控制屏蔽系统的结果表明，头部和肺部所接受的剂量分别降低至规定剂量的93.1%和87.4%。此外，结果表明，使用图像引导系统可以轻松确认屏蔽系统的位置。
一种能够根据大鼠大小控制剂量输送的屏蔽装置，可以优化大鼠肺移植中TLI的剂量。
