Liverpool and Macarthur Cancer Therapy Centres and Ingham Institute, Liverpool, NSW, 2170, Australia.
Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, 2522, Australia.
Med Phys. 2018 Mar;45(3):1266-1275. doi: 10.1002/mp.12742. Epub 2018 Jan 24.
The aim of this study was to demonstrate a new model for implementing a transit dosimetry system as a means of in vivo dose verification with a water equivalent electronic portal imaging device (WE-EPID) and a conventional treatment planning system (TPS).
A standard amorphous silicon (a-Si) EPID was modified to a WE-EPID configuration by replacing the metal-plate/phosphor screen situated above the photodiode detector with a 3 cm thick water equivalent plastic x ray converter material. A clinical TPS was used to calculate dose to the WE-EPID in its conventional EPID position behind the phantom/patient. The "extended phantom" concept was used to facilitate dose calculation at the EPID position, which is outside the CT field of view (FOV). The CT images were manipulated from 512 × 512 into 1024 × 1024 and padded pixels were assigned the density of air before importing to the TPS. The virtual WE-EPID was added as an RT structure of water density at the EPID plane. The accuracy of TPS dose calculations at the EPID plane in transit geometry was first evaluated for different field sizes and thickness of object in the beam by comparison with the dose measured using a 2D ion chamber array (ICA) and the WE-EPID. Following basic dose response tests, clinical fields including direct single fields (open and wedged) and modulated fields (integrated or control point by control point doses for VMAT) were measured for 6 MV photons with varying of solid water thickness or an anthropomorphic phantom present in beam. The EPID images were corrected for dark signal and pixel sensitivity and converted to dose using a single dose calibration factor. The 2D dose evaluation was conducted using 3%/3 and 2%/2 mm gamma-index criteria.
The measured dose-response with the ICA and WE-EPID for all basic dose-response tests agreed with TPS dose calculations to within 1.5%. The maximum difference in dose profiles for the largest measured field size of 25 × 25 cm was 2.5%. Gamma evaluation showed at least 94% (3%/3 mm criteria) and 90% (2%/2 mm) agreement in both integrated and control-point doses for all clinical fields acquired by the WE-EPID and ICA when compared with TPS-calculated portal dose images.
A new approach to transit dose verification has been demonstrated utilizing a water equivalent EPID and a commercial TPS. The accuracy of dose calculations at the EPID plane using a commercial TPS beam model was experimentally confirmed. The model proposed in this study provides an accurate method to directly verify doses delivered during treatment without the additional uncertainties inherent in modelling the complex dose-response of standard EPIDs.
本研究旨在展示一种新的模型,通过使用水等效电子射野影像装置(WE-EPID)和常规治疗计划系统(TPS)实现传输剂量验证。
标准非晶硅(a-Si)EPID 通过将位于光电二极管探测器上方的金属板/荧光屏替换为 3cm 厚的水等效塑料 X 射线转换器材料,改装为 WE-EPID 配置。临床 TPS 用于计算在模体/患者后面的常规 EPID 位置处的 WE-EPID 剂量。使用“扩展模体”概念来促进在 EPID 位置(超出 CT 视野(FOV)之外)的剂量计算。将 CT 图像从 512×512 转换为 1024×1024,并在导入 TPS 之前为填充像素分配空气密度。将虚拟 WE-EPID 添加为 EPID 平面处的水密度的 RT 结构。首先通过将二维电离室阵列(ICA)和 WE-EPID 测量的剂量与 TPS 剂量计算进行比较,评估了不同射野大小和射束中物体厚度的 TPS 剂量计算在传输几何中的准确性。进行了基本剂量响应测试后,用 6MV 光子测量了包括直接单野(开放和楔形)和调制野(调强或控制点剂量的 VMAT)在内的临床野,其中在射束中存在固体水厚度或人体模体。使用单个剂量校准因子将 EPID 图像校正暗信号和像素灵敏度,并转换为剂量。使用 3%/3 和 2%/2mm 的伽马指数标准进行二维剂量评估。
对于所有基本剂量响应测试,ICA 和 WE-EPID 的测量剂量响应与 TPS 剂量计算的一致性在 1.5%以内。对于最大测量射野尺寸为 25×25cm 的剂量分布,最大差异为 2.5%。伽马评估显示,当与 TPS 计算的门户剂量图像进行比较时,通过 WE-EPID 和 ICA 采集的所有临床野的积分和控制点剂量均至少有 94%(3%/3mm 标准)和 90%(2%/2mm)的一致性。
本研究利用水等效 EPID 和商业 TPS 展示了一种新的传输剂量验证方法。使用商业 TPS 光束模型在 EPID 平面上计算剂量的准确性已通过实验得到证实。该研究提出的模型提供了一种直接验证治疗期间所施剂量的准确方法,而无需对标准 EPID 的复杂剂量响应进行建模所带来的额外不确定性。