Kamalian Aida, Khodadadifar Tina, Saberi Amin, Masoudi Maryam, Camilleri Julia A, Eickhoff Claudia R, Zarei Mojtaba, Pasquini Lorenzo, Laird Angela R, Fox Peter T, Eickhoff Simon B, Tahmasian Masoud
School of Medicine Tehran University of Medical Sciences Tehran Iran.
School of Cognitive Sciences Institute for Research in Fundamental Sciences Tehran Iran.
Alzheimers Dement (Amst). 2022 May 29;14(1):e12318. doi: 10.1002/dad2.12318. eCollection 2022.
Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings.
We used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best-practice neuroimaging meta-analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and controls from 73 studies were extracted and tested for convergence using activation likelihood estimation.
We identified convergent abnormalities in the anterior cingulate cortices, anterior insula, amygdala, paracingulate, striatum, and hippocampus. Task-based and resting-state functional connectivity pointed to the networks that are connected to the obtained consistent regions. Functional decoding analyses suggested associated dysfunction of emotional processing, interoception, reward processing, higher-order cognitive functions, and olfactory and gustatory perceptions in bvFTD.
Our findings highlighted the key role of the salience network and subcortical regions in the pathophysiology of bvFTD.
众多研究报告了行为变异型额颞叶痴呆（bvFTD）患者的脑部改变。然而，这些研究结果并不一致。
我们采用荟萃分析方法来确定bvFTD患者大脑在结构和功能上的趋同异常。按照当前最佳实践的神经影像学荟萃分析指南，我们检索了PubMed和Embase数据库并进行参考文献追踪。然后，提取了73项研究中bvFTD患者与对照组之间的组间比较坐标，并使用激活可能性估计法对其进行趋同检验。
我们确定了前扣带回皮质、前岛叶、杏仁核、旁扣带回、纹状体和海马体中的趋同异常。基于任务和静息状态的功能连接指向了与所获得的一致区域相连的网络。功能解码分析表明，bvFTD患者存在情绪加工、内感受、奖赏加工、高阶认知功能以及嗅觉和味觉感知方面的相关功能障碍。
我们的研究结果突出了突显网络和皮质下区域在bvFTD病理生理学中的关键作用。
