Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China.
Hum Brain Mapp. 2021 Oct 15;42(15):5154-5169. doi: 10.1002/hbm.25602. Epub 2021 Jul 23.
Anorexia nervosa (AN) is a complex psychiatric disorder with poorly understood etiology. Numerous voxel-based morphometry (VBM) and resting-state functional imaging studies have provided strong evidence of abnormal brain structure and intrinsic and functional activities in AN, but with inconsistent conclusions. Herein, a whole-brain meta-analysis was conducted on VBM (660 patients with AN, and 740 controls) and resting-state functional imaging (425 patients with AN, and 461 controls) studies that measured differences in the gray matter volume (GMV) and intrinsic functional activity between patients with AN and healthy controls (HCs). Overall, patients with AN displayed decreased GMV in the bilateral median cingulate cortex (extending to the bilateral anterior and posterior cingulate cortex), and left middle occipital gyrus (extending to the left inferior parietal lobe). In resting-state functional imaging studies, patients with AN displayed decreased resting-state functional activity in the bilateral anterior cingulate cortex and bilateral median cingulate cortex, and increased resting-state functional activity in the right parahippocampal gyrus. This multimodal meta-analysis identified reductions of gray matter and functional activity in the anterior and median cingulate in patients with AN, which contributes to further understanding of the pathophysiology of AN.
神经性厌食症（AN）是一种复杂的精神障碍，其病因尚不清楚。大量的基于体素的形态测量学（VBM）和静息态功能成像研究为 AN 的异常脑结构和内在及功能活动提供了有力证据，但结论并不一致。在此，对 VBM（660 例 AN 患者和 740 例对照）和静息态功能成像（425 例 AN 患者和 461 例对照）研究进行了全脑荟萃分析，这些研究测量了 AN 患者和健康对照者（HCs）之间灰质体积（GMV）和内在功能活动的差异。总的来说，AN 患者双侧中央扣带回（延伸至双侧前后扣带回）和左侧中枕叶（延伸至左侧顶下小叶）的 GMV 减少。在静息态功能成像研究中，AN 患者双侧前扣带回和双侧中央扣带回的静息态功能活动减少，右侧海马旁回的静息态功能活动增加。这项多模态荟萃分析确定了 AN 患者前扣带和中央扣带的灰质和功能活动减少，有助于进一步了解 AN 的病理生理学。
