Bhosale Pritam Bhagwan, Kim Hun Hwan, Abusaliya Abuyaseer, Vetrivel Preethi, Ha Sang Eun, Park Min Yeong, Lee Ho Jeong, Kim Gon Sup
Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju 52828, Republic of Korea.
Biological Resources Research Group, Gyeongnam Department of Environmental Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of Korea.
Evid Based Complement Alternat Med. 2022 May 26;2022:9797929. doi: 10.1155/2022/9797929. eCollection 2022.
The transcriptional machinery is composed of numerous factors that help to regulate gene expression in cells. The function and the fundamental role of transcription factors in different human diseases and cancer have been extensively researched. Activator protein-1 (AP-1) is an inducible transcription factor that consists of a diverse group of members including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as proliferation, migration, and survival in cells. Dysfunctional AP-1 activity is seen in several diseases, especially cancer and inflammatory disorders. The AP-1 proteins are controlled by mitogen-activated protein kinases (MAPKs) and the NF-B pathway. AP-1 inhibitors can be actively pursued as drug discovery targets in cancer therapy when used as a treatment to halt tumor progression. The consumption of phytochemicals in the diet is related to decreasing the incidence of cancer and proves to exhibit anticancer properties. Natural product targets AP-1 are effective cancer prevention and treatment options for various cancer types. Targeting AP-1 with natural products is an effective cancer treatment option for different cancer types. This review summarizes AP-1 subunit proteins, their structures, AP-1-related signaling, and its modulation by natural bioactive compounds.
转录机制由众多有助于调节细胞基因表达的因子组成。转录因子在不同人类疾病和癌症中的功能及基本作用已得到广泛研究。活化蛋白-1（AP-1）是一种可诱导的转录因子，由包括Jun、Fos、Maf和ATF在内的多种成员组成。AP-1涉及细胞增殖、迁移和存活等多个过程。在几种疾病中，尤其是癌症和炎症性疾病中，可观察到AP-1活性异常。AP-1蛋白受丝裂原活化蛋白激酶（MAPK）和核因子κB（NF-κB）信号通路调控。当用作阻止肿瘤进展的治疗方法时，AP-1抑制剂可作为癌症治疗中药物研发的靶点积极探索。饮食中植物化学物质的摄入与降低癌症发病率相关，并被证明具有抗癌特性。靶向AP-1的天然产物是针对各种癌症类型的有效癌症预防和治疗选择。用天然产物靶向AP-1是针对不同癌症类型的有效癌症治疗选择。本综述总结了AP-1亚基蛋白、其结构、与AP-1相关的信号传导以及天然生物活性化合物对其的调节作用。
