Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, 263 136, Uttarakhand, India.
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 1435916471, Iran.
Pharmacol Res. 2018 Feb;128:366-375. doi: 10.1016/j.phrs.2017.09.014. Epub 2017 Sep 23.
Activator protein 1 (AP-1) is a key transcription factor in the control of several cellular processes responsible for cell survival proliferation and differentiation. Dysfunctional AP-1 expression and activity are involved in several severe diseases, especially inflammatory disorders and cancer. Therefore, targeting AP-1 has recently emerged as an attractive therapeutic strategy for cancer prevention and therapy. This review summarizes our current understanding of AP-1 biology and function as well as explores and discusses several natural bioactive compounds modulating AP-1-associated signaling pathways for cancer prevention and intervention. Current limitations, challenges, and future directions of research are also critically discussed.
激活蛋白 1（AP-1）是控制细胞存活、增殖和分化等多个细胞过程的关键转录因子。AP-1 表达和功能失调与多种严重疾病有关，尤其是炎症性疾病和癌症。因此，靶向 AP-1 已成为癌症预防和治疗的一种有吸引力的治疗策略。本文综述了我们目前对 AP-1 生物学和功能的理解，并探讨和讨论了几种调节与 AP-1 相关的信号通路的天然生物活性化合物，以预防和干预癌症。还批判性地讨论了当前研究的局限性、挑战和未来方向。
