严重 COVID-19 的主要遗传风险因素与预防 HIV 感染有关。
The major genetic risk factor for severe COVID-19 is associated with protection against HIV.
机构信息
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany;
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
出版信息
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2116435119.
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo, 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.
有一些遗传风险因素会影响 COVID-19 的结果[COVID-19 宿主遗传学倡议，600，472-477（2021）]。严重 COIVD-19 的主要遗传风险因素位于第 3 号染色体上，是从尼安德特人那里遗传下来的[H. Zeberg，S. Pääbo，587，610-612（2020）]。与风险相关的 DNA 片段调节了几种趋化因子受体的表达，其中包括 CCR5，它是 HIV 的一个辅助受体，在 COVID-19 风险单倍型携带者中下调。在这里，我表明，该风险变体的携带者感染 HIV 的风险降低了约 27%。
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