Chen Min, Li Yuhang, Cheng Bo, Zhang Qi, Liu Xin, Wang Kaijun
Eye Center, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China.
Front Med (Lausanne). 2022 May 19;9:902716. doi: 10.3389/fmed.2022.902716. eCollection 2022.
Bilateral congenital ectropion uveae (CEU) is rare syndrome, usually accompanied by refractory glaucoma. Proper and timely treatment was very important for the prognosis. The report aims to compare the long-term outcomes and complications between the two eyes after different approaches of surgery in a case of bilateral CEU with advanced glaucoma.
The patient was a 20-year-old male with bilateral CEU and glaucoma. The intraocular pressure (IOP) was 48 mm Hg in the right eye (OD) and 52 mm Hg in the left eye (OS). The vertical cup-to-disc (C/D) ratio was nearly 1.0 in both eyes. Despite maximum medical therapy, the target IOP could not be achieved. Therefore, CO laser-assisted sclerectomy surgery (CLASS) was performed in OS, and the IOP was remarkably decreased. 1 month after the surgery, the IOP rebounded slightly and was controlled with a fixed-combination anti-glaucoma medicine. 3-month postoperatively, a YAG laser goniopuncture (LGP) was performed to enhance the IOP-lowing effect and the anti-glaucoma agent was discontinued. An ab externo microcatheter-assisted trabeculotomy (MAT) was performed in OD, and the IOP was also significantly decreased. During the follow-up period, the IOP was well controlled for both eyes without any medication. Shallow anterior chamber and complicated cataract developed in OS after CLASS, and there was no obvious late complication in OD after MAT.
To our knowledge, this was the first attempt to perform two different surgeries, CLASS and MAT, in both eyes of a single patient presented with bilateral CEU with glaucoma. Our results showed that the IOP was lower after CLASS, but there were potential complications such as shallow anterior chamber and complicated cataract. MAT could achieve a moderate IOP-lowing effect but had a higher safety. CLASS and MAT may be considered effective surgical options for the management of such patients.
双侧先天性葡萄膜外翻(CEU)是一种罕见的综合征,通常伴有难治性青光眼。恰当及时的治疗对预后非常重要。本报告旨在比较一例双侧CEU伴晚期青光眼患者采用不同手术方式后双眼的长期疗效和并发症。
该患者为一名20岁男性,患有双侧CEU和青光眼。右眼(OD)眼压为48 mmHg,左眼(OS)眼压为52 mmHg。双眼垂直杯盘比(C/D)接近1.0。尽管进行了最大程度的药物治疗,仍无法达到目标眼压。因此,对OS眼进行了CO2激光辅助巩膜切除术(CLASS),眼压显著降低。术后1个月,眼压略有反弹,使用固定复方抗青光眼药物进行控制。术后3个月,进行了YAG激光前房角穿刺术(LGP)以增强降眼压效果并停用抗青光眼药物。对OD眼进行了外路微导管辅助小梁切开术(MAT),眼压也显著降低。在随访期间,双眼眼压无需药物即可得到良好控制。CLASS术后OS眼出现浅前房和复杂性白内障,MAT术后OD眼未出现明显的晚期并发症。
据我们所知,这是首次尝试在一名患有双侧CEU伴青光眼的患者双眼上进行两种不同的手术,即CLASS和MAT。我们的结果表明,CLASS术后眼压较低,但存在浅前房和复杂性白内障等潜在并发症。MAT可实现适度的降眼压效果,但安全性较高。CLASS和MAT可被视为治疗此类患者的有效手术选择。