Department of Gastronomy Sciences and Functional Foods, Poznań University of Life Sciences, Poland.
Department of Non-Food Products Quality and Packaging Development, Poznań University of Economics and Business, Poland.
Biomed Pharmacother. 2022 Aug;152:113216. doi: 10.1016/j.biopha.2022.113216. Epub 2022 Jun 2.
Cornelian cherry (Cornus mas L.) has broad and multidimensional potential in preventing civilisational diseases. Part of these diseases results from DNA oxidative mutations. Thus, the paper aimed to predict how phenolics present in C. mas may interact with dsDNA in ab initio experiment and to check the effect of different cornelian cherry extracts on DNA structure and DNA oxidation. A special research model was designed using biosensor with a carbonpaste electrode. We resulted in various effects observed for phenolics and the extracts. Flavonoids, but of vitexin interacted with declining energy of the DNA models and liability of DNA oxidation. However, for 8-oxoguaniosine the trend was the opposite. Among the evaluated extracts, water-ethanolic extracts caused decline in adenine and guanine signals after dsDNA exposition on the extract. Principal component analysis showed that alcoholic extracts of cv. Szafer and Słowianin, which were rich in apigenin and kaempferol exhibit mild genoprotective effect.
山茱萸（Cornus mas L.）在预防文明病方面具有广泛而多维的潜力。这些疾病部分是由 DNA 氧化突变引起的。因此，本文旨在预测山茱萸中存在的酚类物质如何在从头计算实验中与 dsDNA 相互作用，并检查不同山茱萸提取物对 DNA 结构和 DNA 氧化的影响。使用带有碳糊电极的生物传感器设计了一个特殊的研究模型。我们观察到酚类物质和提取物的各种作用。类黄酮，特别是牡荆素与 DNA 模型的能量下降和 DNA 氧化的易感性有关。然而，对于 8-氧鸟嘌呤核苷则相反。在所评估的提取物中，水-乙醇提取物在 dsDNA 暴露于提取物后导致腺嘌呤和鸟嘌呤信号下降。主成分分析表明，富含芹菜素和山奈酚的 cv.Szafer 和 Słowianin 的醇提物表现出温和的基因保护作用。
