Singh Harpreet, Mishra Arun Kumar, Mohanto Sourav, Kumar Arvind, Mishra Amrita, Amin Ruhul, Darwin Chellappan Ronald, Emran Talha Bin
School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh.
SOS School of Pharmacy, IFTM University, Moradabad, Uttar Pradesh.
Ann Med Surg (Lond). 2024 Aug 7;86(10):5877-5913. doi: 10.1097/MS9.0000000000002392. eCollection 2024 Oct.
Constant exposure to harmful substances from both inside and outside the body can mess up the body's natural ways of keeping itself in balance. This can cause severe skin damage, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. However, plant-derived compounds found in fruits and vegetables have been shown to protect against skin cancer-causing free radicals and other harmful substances. It has been determined that these dietary phytochemicals are effective in preventing skin cancer and are widely available, inexpensive, and well-tolerated. Studies have shown that these phytochemicals possess anti-inflammatory, antioxidant, and antiangiogenic properties that can aid in the prevention of skin cancers. In addition, they influence crucial cellular processes such as angiogenesis and cell cycle control, which can halt the progression of skin cancer. The present paper discusses the benefits of specific dietary phytochemicals found in fruits and vegetables, as well as the signaling pathways they regulate, the molecular mechanisms involved in the prevention of skin cancer, and their drawbacks.
持续接触来自身体内外的有害物质会扰乱身体自身保持平衡的自然方式。这可能导致严重的皮肤损伤，包括基底细胞癌（BCC）、鳞状细胞癌（SCC）和黑色素瘤。然而，水果和蔬菜中发现的植物源化合物已被证明可以抵御导致皮肤癌的自由基和其他有害物质。已确定这些膳食植物化学物质在预防皮肤癌方面有效，且广泛可得、价格低廉且耐受性良好。研究表明，这些植物化学物质具有抗炎、抗氧化和抗血管生成特性，有助于预防皮肤癌。此外，它们会影响诸如血管生成和细胞周期控制等关键细胞过程，从而可以阻止皮肤癌的进展。本文讨论了水果和蔬菜中特定膳食植物化学物质的益处、它们调节的信号通路、预防皮肤癌所涉及的分子机制以及它们的缺点。
