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目前,DevTox Berlin 研讨会与日本畸胎学协会术语委员会之间正在开展活动,旨在协调发育毒性研究中用于分类实验动物异常的术语:来自日本畸胎学协会第 60 届年会卫星研讨会的报告。

Current activities between the DevTox Berlin workshops and the Japanese Teratology Society Terminology Committee in harmonizing the terminology for classifying anomalies in laboratory animals in developmental toxicity studies: Report from the Satellite Workshop of the 60th Annual Meeting of the Japanese Teratology Society.

机构信息

National Institute of Health Sciences, Kawasaki, Japan.

Institute of Environmental Toxicology, Ibaraki, Japan.

出版信息

Congenit Anom (Kyoto). 2022 Sep;62(5):198-202. doi: 10.1111/cga.12480. Epub 2022 Jun 19.

Abstract

In recent years, the Japanese Teratology Society has worked with the DevTox Berlin Workshops project to provide internationally consistent terminology for teratogenic effects. This paper summarizes a satellite workshop of the 60th Annual Meeting of the Japanese Teratology Society, which was entitled "Current activities between DevTox Berlin Workshops to develop a harmonized terminology for classifying anomalies in laboratory animals in developmental toxicity studies." The Japanese Teratology Society - Laboratory Animal Terminology Project (JTS-LATP) reviewed "gray zone" anomalies and focused on developing criteria for reclassifying a large number of gray zone anomalies to clarify them and to make it easier to judge fetal categories. This effort will lead to international agreement, based on shared conceptions. The present article aimed to provide the reader with a summary of the issues discussed at the 2020 satellite meeting, which included discussions on open issues from the DevTox Berlin Workshops, ongoing work by the JTS-LATP on gray zone (GZ) anomalies, current industrial concerns, and future challenges.

摘要

近年来,日本畸胎学学会与 DevTox Berlin Workshops 项目合作,为致畸作用提供国际一致的术语。本文总结了第 60 届日本畸胎学学会年会的一次卫星研讨会,题为“DevTox Berlin Workshops 之间目前的活动,以制定用于分类发育毒性研究中实验动物异常的协调术语”。日本畸胎学学会-实验动物术语项目(JTS-LATP)审查了“灰色区域”异常,并专注于制定重新分类大量灰色区域异常的标准,以澄清这些异常并更轻松地判断胎儿类别。这一努力将基于共同概念达成国际协议。本文旨在为读者提供 2020 年卫星会议讨论问题的摘要,包括来自 DevTox Berlin Workshops 的开放性问题讨论、JTS-LATP 对灰色区域(GZ)异常的持续工作、当前工业关注问题以及未来挑战。

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