Solecki Roland, Rauch Martina, Gall Andrea, Buschmann Jochen, Clark Ruth, Fuchs Antje, Kan Haidong, Heinrich Verena, Kellner Rupert, Knudsen Thomas B, Li Weihua, Makris Susan L, Ooshima Yojiro, Paumgartten Francisco, Piersma Aldert H, Schönfelder Gilbert, Oelgeschläger Michael, Schaefer Christof, Shiota Kohei, Ulbrich Beate, Ding Xuncheng, Chahoud Ibrahim
Federal Institute for Risk Assessment, Germany.
Fraunhofer Institute for Toxicology and Experimental Medicine, Germany.
Reprod Toxicol. 2015 Nov;57:140-6. doi: 10.1016/j.reprotox.2015.06.046. Epub 2015 Jun 11.
This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes.
本文是关于2014年5月举办的第八届柏林发育毒性研讨会的报告。该研讨会的主要目的是持续统一用于评估胚胎毒性和胎儿毒性结果的术语，并创新相关方法。讨论的主要议题如下：将外部、骨骼、内脏及母胎结果统一分类为畸形、变异和灰色地带异常；人类和实验动物发育异常的相关方面；发育毒理学新方法的创新。在DevTox数据库中应用第2版术语被认为是发育异常分类方面的一项有益改进。与会者得出结论，启动一项关于人类和实验动物发育异常比较评估的项目，可为监管风险评估和大学培训提供支持。应推动改进动物试验替代方法的新方法，以更好地了解发育结果。
