Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
Department of Chemistry, Ludwig-Maximilians-Universität München, 81377, München, Germany.
Chemistry. 2022 Aug 16;28(46):e202201179. doi: 10.1002/chem.202201179. Epub 2022 Jun 24.
A highly water- and air-stable Fe(II) complex with the quinol-containing macrocyclic ligand H qp4 reacts with H O to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para-quinones. The reaction increases the T -weighted relaxivity over four-fold, enabling the complex to detect H O using clinical MRI technology. The iron-containing sensor differs from its recently characterized manganese analog, which also detects H O , in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity.
一种高度水稳定和空气稳定的 Fe(II)配合物，具有含喹啉的大环配体 H qp4，与 H 2 O 反应生成配体具有较低螯合形式的 Fe(III)配合物，这些配合物具有一个或两个对位醌。该反应使 T 2 加权弛豫率提高了四倍以上，使该配合物能够使用临床 MRI 技术检测 H 2 O。与最近表征的锰类似物不同，该含铁传感器也检测 H 2 O，但它主要增强弛豫率的是金属中心的氧化，而不是配体。
