Kadakia Rahul T, Ryan Raphael T, Cooke Daniel J, Que Emily L
Department of Chemistry, University of Texas at Austin 105 E 24th St. Stop A5300 Austin TX 78712 USA
Chem Sci. 2023 Apr 14;14(19):5099-5105. doi: 10.1039/d2sc05222a. eCollection 2023 May 17.
We report a first-in-class responsive, pentafluorosulfanyl (-SF)-tagged F MRI agent capable of reversibly detecting reducing environments an Fe redox couple. In the Fe form, the agent displays no F MR signal due to paramagnetic relaxation enhancement-induced signal broadening; however, upon rapid reduction to Fe with one equivalent of cysteine, the agent displays a robust F signal. Successive oxidation and reduction studies validate the reversibility of the agent. The -SF tag in this agent enables 'multicolor imaging' in conjunction with sensors containing alternative fluorinated tags and this was demonstrated simultaneous monitoring of the F MR signal of this -SF agent and a hypoxia-responsive agent containing a -CF group.
我们报道了一种一流的响应性、带有五氟硫烷基（-SF）标记的功能磁共振成像（fMRI）剂，它能够可逆地检测还原环境——铁氧化还原对。在Fe形式下，由于顺磁弛豫增强导致信号展宽，该剂不显示fMRI信号；然而，用一当量的半胱氨酸快速还原为Fe²⁺时，该剂显示出强烈的氟信号。连续的氧化和还原研究验证了该剂的可逆性。该剂中的-SF标签能够与含有其他氟化标签的传感器一起实现“多色成像”，这在同时监测该-SF剂和含有-CF₃基团的缺氧响应剂的fMRI信号中得到了证明。
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