Pye A
Arch Otorhinolaryngol. 1987;243(6):411-6. doi: 10.1007/BF00464654.
Albino and pigmented guinea pigs were exposed to 20 kHz at 120 dB SPL for exposure durations of 30, 7.5, 6.5, 5 and 3.25 min. In a second series of experiments, the two shortest exposures were repeated after an interval of 6 or 24 h. Sensory hair cell loss was assessed 3 weeks post-exposure by surface preparations and quantified as percentage cell loss per segment per row, total numbers of outer and inner hair cells lost and the area of total outer hair cell damage. A variable but discrete area of damage resulted from these exposures. The main differences between the two strains were that in albino guinea pigs fewer ears were damaged after the shortest single exposures and generally more damage occurred after repeated exposures. However, no differences were detected in either strain when the interval between repeated exposures was changed.
将白化豚鼠和有色豚鼠暴露于120分贝声压级的20千赫声音中，暴露持续时间分别为30、7.5、6.5、5和3.25分钟。在第二组实验中，间隔6或24小时后重复进行两次最短时间的暴露。暴露3周后，通过表面制备评估感觉毛细胞损失情况，并量化为每行每段的细胞损失百分比、损失的外毛细胞和内毛细胞总数以及外毛细胞总损伤面积。这些暴露导致了不同但离散的损伤区域。两种品系之间的主要差异在于，在白化豚鼠中，单次最短暴露后受损的耳朵较少，而重复暴露后通常损伤更多。然而，当改变重复暴露之间的间隔时，在任何一个品系中均未检测到差异。
