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不同暴露时间的声学创伤效应。

Acoustic trauma effects with varying exposure times.

作者信息

Pye A

出版信息

Arch Otorhinolaryngol. 1981;230(3):265-71. doi: 10.1007/BF00456328.

DOI:10.1007/BF00456328
PMID:7023441
Abstract

Guinea pigs have been exposed to 20 kHz for 2 h, 1 h, 30 min, 15 min, or 7.5 min, and the resultant damage was observed 3, 6, and 12 weeks post exposure. The areas of outer hair cell damage were statistically compared. Significant differences were obtained after a 3-week survival time with the shorter exposure times, but this difference was no longer apparent after 12 weeks. Myelinated nerve fibre and inner hair cell damage occurred only with total outer hair cell loss.

摘要

豚鼠暴露于20千赫兹的环境中2小时、1小时、30分钟、15分钟或7.5分钟,并在暴露后3周、6周和12周观察由此产生的损伤。对外毛细胞损伤的面积进行了统计学比较。在3周的存活期后,较短的暴露时间产生了显著差异,但在12周后这种差异不再明显。有髓神经纤维和内毛细胞损伤仅在全部外毛细胞丧失时才会发生。

相似文献

1
Acoustic trauma effects with varying exposure times.不同暴露时间的声学创伤效应。
Arch Otorhinolaryngol. 1981;230(3):265-71. doi: 10.1007/BF00456328.
2
Neural damage in the guinea pig cochlea after noise exposure. A light microscopic study.
Acta Otolaryngol. 1976 Jul-Aug;82(1-2):82-94. doi: 10.3109/00016487609120865.
3
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Effects of acoustic trauma on stereocilia structure and spiral ganglion cell tuning properties in the guinea pig cochlea.噪声性损伤对豚鼠耳蜗静纤毛结构及螺旋神经节细胞调谐特性的影响。
Hear Res. 1982 May;7(1):55-74. doi: 10.1016/0378-5955(82)90081-8.
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Changes of hair cell stereocilia and threshold shift after acoustic trauma in guinea pigs: comparison between inner and outer hair cells.豚鼠声损伤后毛细胞静纤毛变化及阈值偏移:内毛细胞与外毛细胞的比较
ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):266-74. doi: 10.1159/000075224.

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BMC Neurosci. 2012 Jun 19;13:71. doi: 10.1186/1471-2202-13-71.
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Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis.在噪声诱导的耳蜗发病机制中,黏附相关基因的转录变化具有特定部位的特异性。
Neurobiol Dis. 2012 Feb;45(2):723-32. doi: 10.1016/j.nbd.2011.10.018. Epub 2011 Oct 25.
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Acoustic overstimulation modifies Mcl-1 expression in cochlear sensory epithelial cells.

本文引用的文献

1
Hair cell damage in the guinea pig due to different kinds of noise.
Acta Otolaryngol Suppl. 1980;367:1-43. doi: 10.3109/00016488009124953.
2
Relation of structural damage to exposure time and intensity in acoustic trauma.
Acta Otolaryngol. 1973 Feb-Mar;75(2):220-6. doi: 10.3109/00016487309139699.
3
Acoustic trauma effects from doubling the exposure time.暴露时间加倍会产生声学创伤效应。
Br J Audiol. 1978 May;12(2):51-3. doi: 10.3109/03005367809078853.
4
声过载刺激可改变耳蜗感觉上皮细胞中 Mcl-1 的表达。
J Neurosci Res. 2010 Jun;88(8):1812-21. doi: 10.1002/jnr.22333.
4
The effects of short noise exposures in the guinea pig.短时间噪声暴露对豚鼠的影响。
Arch Otorhinolaryngol. 1984;240(2):107-14. doi: 10.1007/BF00453467.
5
Comparison of various short noise exposures in albino and pigmented guinea pigs.白化豚鼠和有色豚鼠不同短时间噪声暴露的比较。
Arch Otorhinolaryngol. 1987;243(6):411-6. doi: 10.1007/BF00464654.
Acoustic trauma effects from doubling the exposure time.
暴露时间加倍会产生声学创伤效应。
Arch Otorhinolaryngol. 1979;224(1-2):107-9. doi: 10.1007/BF00455232.