Teagasc Food Research Centre, Ashtown, Dublin 15 D15 KN3K, Ireland.
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, U.K.
J Agric Food Chem. 2022 Jun 15;70(23):7248-7257. doi: 10.1021/acs.jafc.2c00843. Epub 2022 Jun 6.
Nitrovin (NTV) belongs to a class of antibiotics called nitrofurans, which are classified as nonallowed pharmacologically active substances that do not have a maximum residue limit listed in EU legislation. The objectives of this study were to confirm aminoguanidine (AGN) as a suitable marker residue to monitor NTV abuse and to investigate its persistence in porcine tissues. In this work, pigs were fed with NTV-medicated feed (50 mg/kg), and tissues (kidney, muscle, and liver) and plasma were collected on different withdrawal days. All samples were analyzed for bound AGN, total AGN, and the parent drug NTV itself. The highest concentrations of AGN residues were found in the liver, while the lowest were in muscle. Parent NTV was only detected in the kidney at low levels on day 0 of withdrawal. The findings are in support of using AGN as the marker residue for monitoring the illegal use of NTV in animal-derived products.
硝呋烯腙（NTV）属于一类被称为硝基呋喃类的抗生素，这类抗生素被归类为不允许使用的具有药理活性的物质，在欧盟法规中没有列出最大残留限量。本研究的目的是确认氨基胍（AGN）是一种合适的残留标志物，以监测 NTV 的滥用情况，并研究其在猪组织中的持久性。在这项工作中，猪用含 NTV 的饲料（50mg/kg）喂养，在不同的停药日采集组织（肾脏、肌肉和肝脏）和血浆。所有样品均用于分析结合 AGN、总 AGN 和母体药物 NTV 本身。AGN 残留的最高浓度出现在肝脏中，而在肌肉中最低。母体 NTV 仅在停药第 0 天在肾脏中以低水平检测到。这些发现支持使用 AGN 作为监测动物源性产品中 NTV 非法使用的残留标志物。
