Department of Cardiology, No. 904 Hospital of the PLA Joint Logistic Support Force, Wuxi, China.
J Cardiovasc Pharmacol. 2022 Jun 1;79(6):791-798. doi: 10.1097/FJC.0000000000001245.
Bone morphogenetic protein 4 (BMP4) is a proinflammatory factor. The expression of BMP4 is reduced in the adipose and enhanced in the myocardium and vascular during obesity. It is possibly involved in the process of inflammatory response of the myocardium and vascular. Obesity, often regarded as a risk factor for cardiovascular diseases, is a kind of inflammatory response. This study aimed to investigate the relationship of BMP4 with obesity and cardiovascular disease. Ob/ob mice were used as the experimental group, and C57BL/6 mice were used as the control group. The two groups were further divided into 2 subgroups based on the mice carrying adenovirus-encoding shRNA for BMP4 or Lac Z genes. The messenger RNA and protein levels of BMP4, interleukin-1β, and interleukin-9 were significantly higher in the myocardial tissue and aorta of ob/ob+ Lac Z shRNA than those in the other 3 groups, whereas the levels in the ob/ob+ BMP4 shRNA group were significantly decreased and comparable with those in the control groups. BMP4 is significantly upregulated in the myocardial tissue and aorta of obese mice, and this suggests that BMP4 is an risk factor involved in the local inflammatory response.
骨形态发生蛋白 4（BMP4）是一种促炎因子。在肥胖时，BMP4 在脂肪组织中的表达减少，而在心和血管中增强。它可能参与了心肌和血管的炎症反应过程。肥胖通常被认为是心血管疾病的危险因素，是一种炎症反应。本研究旨在探讨 BMP4 与肥胖和心血管疾病的关系。将肥胖型（ob/ob）小鼠作为实验组，C57BL/6 小鼠作为对照组。根据携带编码 BMP4 或 Lac Z 基因的腺病毒 shRNA 的小鼠，将两组进一步分为 2 个亚组。ob/ob+Lac Z shRNA 组的心肌组织和主动脉中 BMP4、白细胞介素-1β 和白细胞介素-9 的信使 RNA 和蛋白水平明显高于其他 3 组，而 ob/ob+BMP4 shRNA 组的水平明显降低，与对照组相当。肥胖小鼠的心肌组织和主动脉中 BMP4 显著上调，这表明 BMP4 是参与局部炎症反应的危险因素之一。
