Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC.
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC.
Chemosphere. 2022 Sep;303(Pt 3):135203. doi: 10.1016/j.chemosphere.2022.135203. Epub 2022 Jun 3.
The serious situation mandates the use of anticancer drugs, which protect people all over the world from the growth of prostate cancer. In particular, excessive dosage and erroneous discharge of flutamide concentration cause make environmental pollution on the surface of the wastewater. In this study, the highly sensitive and selective electrochemical approach based on copper vanadium oxide decorated porous carbon (denoted as β-CuVO/PC) composite modified glassy carbon electrode (GCE) has been developed and it was applied for sensitive detection of anticancer drug flutamide (FTM). Moreover, using the co-precipitation method, the flower-like β-CuVO hierarchical microstructure was synthesized, and through the wet chemical process, the β-CuVO/PC composite was obtained. The resultant product was characterized by XRD, FTIR, RAMAN, XPS and structural morphology established by FESEM analysis. Besides that, the electrochemical characterization and properties were analyzed by cyclic voltammetry (CV) and amperometric (i-t) techniques. The β-CuVO/PC/RDGCE had two linear ranges at 0.01-2.11 μM and 2.31-30.81 μM. The lower limits of detection and sensitivity were found at 0.62 nM (S/N = 3), and 24.33 μA μM cm respectively. The practicability test was applied for the determination of FTM in urine, blood serum and environmental aquatic fluid with satisfactory recovery obtained.
严峻的形势要求使用抗癌药物，这些药物可以保护全世界的人们免受前列腺癌的侵害。特别是，氟他胺浓度的过量剂量和错误排放会导致废水中表面的环境污染。在这项研究中，基于铜钒氧化物修饰多孔碳（表示为β-CuVO/PC）复合材料修饰的玻碳电极（GCE）的高灵敏度和选择性电化学方法已经得到了发展，并将其应用于抗癌药物氟他胺（FTM）的灵敏检测。此外，通过共沉淀法合成了花状β-CuVO 分级微结构，并通过湿化学过程获得了β-CuVO/PC 复合材料。通过 XRD、FTIR、Raman、XPS 和 FESEM 分析建立的结构形态对所得产物进行了表征。此外，通过循环伏安法（CV）和安培（i-t）技术对电化学特性和性能进行了分析。β-CuVO/PC/RDGCE 在 0.01-2.11 μM 和 2.31-30.81 μM 之间有两个线性范围。检测下限和灵敏度分别为 0.62 nM（S/N = 3）和 24.33 μA μM cm。实际应用测试用于测定尿液、血清和环境水样中的 FTM，获得了令人满意的回收率。
