Luo Yiran, Kasturi P Rupa, Barwa Tara N, Dempsey Eithne, Breslin Carmel B
Department of Chemistry, Maynooth University, Maynooth, Co. Kildare W23 F2H6, Ireland.
Kathleen Lonsdale Institute, Maynooth University, Maynooth, Co. Kildare W23 F2H6, Ireland.
ACS Omega. 2024 Jun 26;9(27):29598-29608. doi: 10.1021/acsomega.4c02795. eCollection 2024 Jul 9.
The development of electrochemical sensors for flutamide detection is a crucial step in biomedical research and environmental monitoring. In this study, a composite of -derived carbon particles (CPs) and tungsten disulfide (WS) was formed and used as an electrocatalyst for the electrochemical detection of flutamide. The CPs had an average diameter of 500 nm and contained surface hydroxyl and carbonyl groups. These groups may help anchor the CPs onto the WS platelets, resulting in the formation of a CPs-WS nanocomposite with a high surface area and a conducting network, enabling electron transfer. Using the CPs-WS composite supported at a glassy carbon electrode, a linear concentration range extending from 1 nM to 104 μM, a limit of detection of 0.74 nM, and a sensitivity of 26.9 ± 0.7 μA μM cm were obtained in the detection of flutamide in a phosphate buffer. The sensor showed good recovery, ranging from 88.47 to 95.02%, in river water samples, and exhibited very good selectivity in the presence of inorganic ions, including Al, Co, Cu, Fe, Zn, NO , SO , CO , and Cl.
用于氟他胺检测的电化学传感器的开发是生物医学研究和环境监测中的关键一步。在本研究中，形成了一种由衍生碳颗粒（CPs）和二硫化钨（WS）组成的复合材料，并将其用作电化学检测氟他胺的电催化剂。CPs的平均直径为500nm，含有表面羟基和羰基。这些基团可能有助于将CPs锚定在WS片层上，从而形成具有高表面积和导电网络的CPs-WS纳米复合材料，实现电子转移。使用支撑在玻碳电极上的CPs-WS复合材料，在磷酸盐缓冲液中检测氟他胺时，获得了从1 nM到104 μM的线性浓度范围、0.74 nM的检测限和26.9±0.7 μA μM cm的灵敏度。该传感器在河水样品中的回收率良好，范围为88.47%至95.02%，并且在包括Al、Co、Cu、Fe、Zn、NO 、SO 、CO 和Cl在内的无机离子存在下表现出非常好的选择性。
