Department of Electro-Optical Engineering, National Taipei University of Technology, Taipei, 10608, Taiwan.
Nanosensor Laboratory, PSG Institute of Advanced Studies, Coimbatore, 641 004, India.
Ecotoxicol Environ Saf. 2021 Jan 1;207:111276. doi: 10.1016/j.ecoenv.2020.111276. Epub 2020 Sep 15.
Aquatic contamination from the accumulation of pharmaceuticals has induced severe toxicological impact to the ecological environment, especially from non-steroidal anti-inflammatory drugs (NSAIDs). Real-time monitoring of flutamide, which is a class of NSAIDs, is very significant in environmental protection. In this work, we have synthesized the hexagonal-h boron nitride decorated on bismuth oxide (BiO/h-BN) based nanocomposite for the effective electrochemical detection of flutamide (FTM). The structural and morphological information of the heterostructured BiO/h-BN nanocomposite was analyzed by using a sequence of characterization methods. Voltammetric techniques were used to evaluate the analytical performance of the BiO/h-BN modified screen-printed carbon electrode (SPCE) for the FTM detection. The BiO/h-BN modified SPCE displays a synergetic catalytic effect for the reduction of FTM due to large surface area, numerous active sites, fast charge transfer and abundant defects. The proposed electrochemical sensing platform demonstrates high selectivity, low detection limit (9.0 nM), good linear ranges (0.04-87 μM) and short response time for the detection of FTM. The feasibility of the electrochemical sensor has been proved by the successful application to determine FTM in environmental samples.
水环境污染是由药物的积累引起的，对生态环境造成了严重的毒理学影响，尤其是非甾体抗炎药（NSAIDs）。实时监测氟他胺（一种 NSAIDs 类药物）在环境保护中非常重要。在这项工作中，我们合成了六方氮化硼修饰的氧化铋（BiO/h-BN）基纳米复合材料，用于氟他胺（FTM）的有效电化学检测。采用一系列表征方法对异质结构 BiO/h-BN 纳米复合材料的结构和形貌信息进行了分析。采用伏安技术评估了 BiO/h-BN 修饰的丝网印刷碳电极（SPCE）对 FTM 检测的分析性能。BiO/h-BN 修饰的 SPCE 由于具有较大的表面积、丰富的活性位点、快速的电荷转移和丰富的缺陷，对 FTM 的还原表现出协同催化作用。所提出的电化学传感平台具有高选择性、低检测限（9.0 nM）、良好的线性范围（0.04-87 μM）和较短的响应时间，可用于检测 FTM。该电化学传感器已成功应用于环境样品中 FTM 的测定，证明了其可行性。
