肌球蛋白轻链激酶抑制剂对大鼠嗜铬细胞瘤PC12h细胞儿茶酚胺分泌的影响。
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells.
作者信息
Nagatsu T, Suzuki H, Kiuchi K, Saitoh M, Hidaka H
出版信息
Biochem Biophys Res Commun. 1987 Mar 30;143(3):1045-8. doi: 10.1016/0006-291x(87)90357-3.
PMID:3566753
Abstract
Release of dopamine from rat pheochromocytoma PC12h cells by high K+ (50 mM) was inhibited by a specific inhibitor of myosin light-chain kinase (ML-9) dose-dependently. The myosin light-chain kinase inhibitor also specifically inhibited the phosphorylation of a 20 KDa protein by myosin light-chain kinase. Myosin light chain kinase may play a stimulatory role in the release reaction of catecholamines from the rat pheochromocytoma cells.
摘要
高钾（50 mM）诱导的大鼠嗜铬细胞瘤PC12h细胞多巴胺释放受到肌球蛋白轻链激酶（ML-9）特异性抑制剂的剂量依赖性抑制。该肌球蛋白轻链激酶抑制剂还特异性抑制了肌球蛋白轻链激酶对一种20 kDa蛋白的磷酸化作用。肌球蛋白轻链激酶可能在大鼠嗜铬细胞瘤细胞儿茶酚胺释放反应中发挥刺激作用。
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