Hypersensitivity to five non-steroidal anti-inflammatory agents: ibuprofen, fenoprofen, indomethacin, naproxen and tolmetin.

Five drugs promoted generally as safe substitutes for aspirin-sensitive individuals (ASA) were studied. All five were found capable of causing exacerbation of symptoms and increase of induced bleeding time in ASA patients with concomitant low iodide tolerance, and four of the five drugs gave positive reactions in patients tolerant to ASA but iodide intolerant.