Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, NO. 150 Haping ST, Nangang District, 150081, Harbin, China.
Department of Interventional Medicine, The First Affiliated Hospital of Harbin Medical University, NO. 23 Post Street, Nangang District, Harbin, Heilongjiang, 150001, China.
BMC Gastroenterol. 2022 Jun 6;22(1):288. doi: 10.1186/s12876-022-02348-0.
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are the most prevalent histologic types of primary liver cancer. HCC and ICC differ in treatment and prognosis, warranting an effective differential diagnosis between them. This study aimed to explore the clinical value of mean platelet volume (MPV) to discriminate between HCC and ICC.
MATERIAL/METHODS: We performed a retrospective analysis of ICC and HCC patients who were from the Harbin Medical University Cancer Hospital, China. Logistic regression analysis was used to identify the independent factors for the differentiation of HCC and ICC. A receiver operating characteristic curve was built to evaluate the diagnostic performance of the potential model. An independent validation study was performed to validate the diagnostic ability.
ICC patients were detected in 146 out of 348 patients in the primary cohort. MPV levels were decreased in ICC patients compared with those in HCC patients. Logistic regression analysis revealed that MPV was an independent factor in distinguishing HCC from ICC. A combination of sex, hepatitis B surface antigen, MPV, alpha-fetoprotein, and carbohydrate antigen 19-9 demonstrated a good capability to differentiate HCC from ICC. Similar results were achieved in the validation cohort.
MPV may be a new marker to help distinguish ICC from HCC. Further validation studies are required.
肝内胆管细胞癌（ICC）和肝细胞癌（HCC）是原发性肝癌最常见的组织学类型。HCC 和 ICC 的治疗和预后不同，因此需要有效地对它们进行鉴别诊断。本研究旨在探讨平均血小板体积（MPV）在鉴别 HCC 和 ICC 中的临床价值。
材料/方法：我们对来自中国哈尔滨医科大学附属肿瘤医院的 ICC 和 HCC 患者进行了回顾性分析。使用逻辑回归分析确定 HCC 和 ICC 鉴别诊断的独立因素。构建受试者工作特征曲线评估潜在模型的诊断性能。进行独立验证研究以验证诊断能力。
在原发性队列中，348 例患者中检测到 146 例 ICC 患者。与 HCC 患者相比，ICC 患者的 MPV 水平降低。逻辑回归分析显示，MPV 是区分 HCC 和 ICC 的独立因素。性别、乙型肝炎表面抗原、MPV、甲胎蛋白和癌抗原 19-9 的组合具有良好的区分 HCC 和 ICC 的能力。验证队列中也得到了类似的结果。
MPV 可能是一种有助于鉴别 ICC 和 HCC 的新标志物。需要进一步的验证研究。
