微小的守门人：宿主药物转运体的微生物调控 - Suppr

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Tiny Gatekeepers: Microbial Control of Host Drug Transporters.

作者信息

Kyaw Than S, Turnbaugh Peter J

机构信息

Department of Microbiology & Immunology, University of California San Francisco, San Francisco, California, USA.

Chan Zuckerberg Biohub, San Francisco, California, USA.

出版信息

Clin Pharmacol Ther. 2022 Sep;112(3):443-445. doi: 10.1002/cpt.2647. Epub 2022 Jun 6.

DOI:10.1002/cpt.2647

PMID:35668713

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9540778/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3559/9540778/0d618bff035d/CPT-112-443-g001.jpg

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Bioaccumulation of therapeutic drugs by human gut bacteria.

Nature. 2021 Sep;597(7877):533-538. doi: 10.1038/s41586-021-03891-8. Epub 2021 Sep 8.

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

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The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine.

Dose Response. 2021 Aug 17;19(3):15593258211033111. doi: 10.1177/15593258211033111. eCollection 2021 Jul-Sep.

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.

Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018. doi: 10.1073/pnas.1920483117. Epub 2020 Jun 22.

A metagenomic strategy for harnessing the chemical repertoire of the human microbiome.

Science. 2019 Dec 13;366(6471). doi: 10.1126/science.aax9176. Epub 2019 Oct 3.

Transporter-Mediated Drug-Drug Interactions and Their Significance.

Adv Exp Med Biol. 2019;1141:241-291. doi: 10.1007/978-981-13-7647-4_5.

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice.

Drug Metab Dispos. 2017 Dec;45(12):1225-1238. doi: 10.1124/dmd.117.077313. Epub 2017 Sep 22.

The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).

J Agric Food Chem. 2013 May 8;61(18):4352-9. doi: 10.1021/jf4007505. Epub 2013 Apr 24.

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88.

Gut. 2012 Aug;61(8):1124-31. doi: 10.1136/gutjnl-2011-301104. Epub 2011 Nov 23.

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