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RNA之谜:“从生命起源到新型冠状病毒-COVID-19”

RNA enigma: "From origin of life to novel Coronavirus-COVID-19".

作者信息

Krishnaveni M, Venkatesh S

机构信息

Immuno-Pharmacology Laboratory, Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Marina Campus, Rajakkamangalam, Kanyakumari, Tamil Nadu, India.

Genetic Engineering and Regenerative Biology Lab, Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.

出版信息

Saudi J Biol Sci. 2022 Jul;29(7):103331. doi: 10.1016/j.sjbs.2022.103331. Epub 2022 Jun 1.

DOI:10.1016/j.sjbs.2022.103331
PMID:35668729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9158322/
Abstract

Recent events of the viral catastrophe have shown the rapidity of spread of new disease through emergence of virulent strains. Proper control measures can be developed only through understanding the evolution of virulence in RNA viruses. To understand the evolution of this novel Coronavirus, COVID-19, it is imperative to delineate the evolution of RNA, its transformation into first life forms, the steady and continuous evolution and emergence through modification in their genome and nevertheless the natural selection. This review will throw light on these aspects to understand the possible origin of COVID-19 to control and eradicate this viral outbreak.

摘要

近期的病毒灾难事件显示了新疾病通过毒力菌株的出现而迅速传播。只有通过了解RNA病毒中毒力的演变,才能制定出适当的控制措施。为了了解这种新型冠状病毒COVID-19的演变,必须描绘RNA的演变、它向第一种生命形式的转变、通过基因组修饰的稳定持续演变和出现,以及自然选择。这篇综述将阐明这些方面,以了解COVID-19的可能起源,从而控制和根除这次病毒爆发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/9201007/475ae7ca0515/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/9201007/c9728c884b59/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/9201007/475ae7ca0515/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/9201007/c9728c884b59/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/9201007/475ae7ca0515/gr1.jpg

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The proximal origin of SARS-CoV-2.严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的近端起源。
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mBio. 2018 Nov 27;9(6):e02329-18. doi: 10.1128/mBio.02329-18.
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Why are RNA virus mutation rates so damn high?为什么 RNA 病毒的突变率如此之高?
PLoS Biol. 2018 Aug 13;16(8):e3000003. doi: 10.1371/journal.pbio.3000003. eCollection 2018 Aug.