Zhou Xin, Mubanga David, Chen Zhuo, Bi Xinling
Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China.
Department of Dermatology, Maina Soko Military Hospital, Lusaka, Zambia.
Clin Cosmet Investig Dermatol. 2022 May 31;15:987-992. doi: 10.2147/CCID.S368390. eCollection 2022.
Cutaneous mucinosis is a rare disease that manifests as an excessive accumulation of mucin in the skin that forms waxy papules or plaques. We report a case of a 44-year-old male psoriatic patient who developed generalized cutaneous mucinosis after 11 months of biological treatment. The patient had a history of psoriasis for 20 years and had been treated with narrow-band UVB phototherapy, methotrexate, or acitretin intermittently. He was started on etanercept after he was diagnosed with psoriatic arthritis, and 11 months later, he complained of swelling in his extremities and myxoid cysts on his fingers. Etanercept was then discontinued due to loss of efficacy and widespread skin lesions. However, the lesions subsided spontaneously after 6 months without specific systemic treatment.
皮肤黏蛋白沉积症是一种罕见疾病，表现为皮肤中黏蛋白过度积聚，形成蜡样丘疹或斑块。我们报告一例44岁男性银屑病患者，在生物治疗11个月后发生泛发性皮肤黏蛋白沉积症。该患者有20年银屑病病史，曾间断接受窄谱中波紫外线光疗、甲氨蝶呤或阿维A治疗。他在被诊断为银屑病关节炎后开始使用依那西普，11个月后，他抱怨四肢肿胀和手指出现黏液样囊肿。由于疗效丧失和广泛的皮肤病变，依那西普随后停药。然而，未经特殊系统治疗，6个月后病变自行消退。
