Mansiroglu Asli Kurtar, Disikirik Tuba, Seymen Hande, Cosgun Mehmet, Sincer Isa
Department of Cardiology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
J Cardiovasc Echogr. 2022 Jan-Mar;32(1):23-28. doi: 10.4103/jcecho.jcecho_65_21. Epub 2022 Apr 20.
Deteriorated aortic elasticity is part of the atherosclerotic process. Inflammation is an underlying factor in both COVID-19 and atherosclerosis.
Using aortic elastic properties, we aimed to assess the subclinical indicators of susceptibility to inflammatory atherosclerosis in patients with COVID-19.
Out of 194 participants included in this study, 100 were diagnosed with COVID-19 in the last 6 months (60 women and 40 men with a mean age of 34.13 ± 6.45 years) and 94 were healthy controls (55 women and 39 men with a mean age of 30.39 ± 7.21 years). We analyzed transthoracic echocardiographic and aortic stiffness parameters in all participants.
Values of systolic blood pressure (110 [85-140] vs. 110 [80-140], = 0.037) and pulse pressure (PP) (37 [25-55] vs. 40 [25-55], < 0.01) were significantly different between the groups. As for laboratory parameters, levels of glucose (97.89 ± 20.23 vs. 92.00 ± 9.95, = 0.003) and creatinine (0.80 ± 0.13 vs. 0.75 ± 0.09, = 0.003) were significantly higher in the COVID-19 group. Echocardiographic parameters showed that both groups differed significantly in diastolic aortic diameter (2.42 ± 0.28 vs. 2.31 ± 0.35, = 0.017), aortic strain (9.66 [1.20-31.82] vs. 12.82 [2.41-40.11], = 0.025), aortic distensibility (0.502 [0.049-2.545] vs. 0.780 [0.120-2.674], < 0.01), and aortic stiffness (16.67 [4.19-139.43] vs. 11.71 [3.43-65.21], = 0.006).
Measurement of aortic stiffness is a simple, practical yet inexpensive method in COVID-19 patients, and therefore, may be used as an early marker for COVID-19-induced subclinical atherosclerosis.
主动脉弹性恶化是动脉粥样硬化过程的一部分。炎症是2019冠状病毒病（COVID-19）和动脉粥样硬化的潜在因素。
利用主动脉弹性特性，我们旨在评估COVID-19患者炎症性动脉粥样硬化易感性的亚临床指标。
在本研究纳入的194名参与者中，100名在过去6个月内被诊断为COVID-19（60名女性和40名男性，平均年龄34.13±6.45岁），94名是健康对照者（55名女性和39名男性，平均年龄30.39±7.21岁）。我们分析了所有参与者的经胸超声心动图和主动脉僵硬度参数。
两组间收缩压（110[85 - 140] vs. 110[80 - 140]，P = 0.037）和脉压（PP）（37[25 - 55] vs. 40[25 - 55]，P < 0.01）值有显著差异。至于实验室参数，COVID-19组的血糖水平（97.89±20.23 vs. 92.00±9.95，P = 0.003）和肌酐水平（0.80±0.13 vs. 0.75±0.09，P = 0.003）显著更高。超声心动图参数显示，两组在舒张期主动脉直径（2.42±0.28 vs. 2.31±0.35，P = 0.017）、主动脉应变（9.66[1.20 - 31.82] vs. 12.82[2.41 - 40.11]，P = 0.025）、主动脉扩张性（0.502[0.049 - 2.545] vs. 0.780[0.120 - 2.674]，P < 0.01）和主动脉僵硬度（16.67[4.19 - 139.43] vs. 11.71[3.43 - 65.21]，P = 0.006）方面有显著差异。
测量主动脉僵硬度对COVID-19患者来说是一种简单、实用且经济的方法，因此，可作为COVID-19诱导的亚临床动脉粥样硬化的早期标志物。
