评估普萘洛尔全身给药对钛植入物周围骨整合的影响：一项在犬类中的组织形态计量学研究。

Evaluating systemic administration effect of propranolol on osseointegration around titanium implants: A histomorphometric study in dogs.

作者信息

Tavakoli Mohammad, Farshami Mohammad Jafari, Torabinia Nakisa, Yaghini Jaber, Shams Samaneh

机构信息

Dental Implant Research Center, Department of Periodontology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.

出版信息

Dent Res J (Isfahan). 2022 Apr 27;19:37. eCollection 2022.

PMID:35669606

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9164661/

Abstract

BACKGROUND

Dental implants are known as a widely accepted and predictable method to replace missing teeth. Many factors, including using a class of drugs, such as β-blockers, can improve the osseointegration of dental implants. This study aimed to investigate the relationship between administrating propranolol and osseointegration in dental implants.

MATERIALS AND METHODS

This experimental animal study was performed on four native male street dogs of 11-13 kg of weight and 16-20 months of age. The specimens underwent teeth extraction. After that, the dogs were randomly divided into two groups. The first group contains two control dogs which would receive oral saline. The second contains two dogs which would receive oral tablets of propranolol daily. After a period of healing, three titanium implants were inserted in each of speciments' left mandibular quadrant, and treatment was resumed with propranolol and saline administration in case and control group, respectively. After 4 weeks, one of control group dogs and one of case group were anesthetized, and dental implants were removed alongside the peripheral bone marrow using a trephine drill. Meanwhile, the other two dogs (1 control and 1 propranolol administered dogs) were anesthetized after 9 weeks of implant placement, and the same procedure was carried out.

RESULTS

Due to the histomorphometric assessment, the mean score of bone implant contact (BIC) in week 4 was significantly higher in case group compared to control one (68.33% vs. 20.22%). In week 9, the mean BIC score was higher in case group compared to control group (68.60% vs. 50.17%); meanwhile, in contrast to week 4, it was not statistically significant. In both case and control groups, the formation of woven and lamellar bone was more significant in week 4 rather than week 9.

CONCLUSION

Administration of systemic β-blockers can improve dental implants osseointegration process.

摘要

背景

牙种植体是一种广泛接受且可预测的缺牙替代方法。许多因素，包括使用一类药物，如β受体阻滞剂，可改善牙种植体的骨整合。本研究旨在探讨给予普萘洛尔与牙种植体骨整合之间的关系。

材料与方法

本实验动物研究对4只体重11 - 13千克、年龄16 - 20个月的本地雄性流浪狗进行。对标本进行拔牙。之后，将狗随机分为两组。第一组包含两只对照狗，给予口服生理盐水。第二组包含两只狗，每天给予口服普萘洛尔片。经过一段时间的愈合后，在每个标本的左下颌象限植入3枚钛种植体，病例组和对照组分别继续给予普萘洛尔和生理盐水。4周后，对1只对照组狗和1只病例组狗进行麻醉，使用环钻将牙种植体连同外周骨髓一起取出。同时，在种植体植入9周后，对另外两只狗（1只对照狗和1只给予普萘洛尔的狗）进行麻醉，并进行相同的操作。