Shen Yanjun, Xu Yawen, Wei Jianying, Li Wendong
Department of Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
J Hepatocell Carcinoma. 2022 May 31;9:467-476. doi: 10.2147/JHC.S369168. eCollection 2022.
This research aimed to comprehensively assess the prognostic role of fibrinogen to prealbumin ratio (FPR) in BCLC A-C HCC patients treated by TACE and RFA.
The research included 240 patients at stage BCLC A-C treated by TACE and RFA at Beijing Ditan Hospital of Capital Medical University from May 2011 to November 2018.
The results showed that the size of the tumor, vascular invasion, α-foetoprotein, cirrhosis, NLR, LMR, and PLR showed prognostic value in predicting 5-year OS. Besides, FPR (95% confidence interval: 1.006-1.013, hazard ratio: 1.009) was a prognostic factor for the prediction of 5-year OS in HCC.
Our research indicated that FPR was a potential indicator for patients with BCLC A-C hepatocellular carcinoma after treatment of RFA and TACE.
本研究旨在全面评估纤维蛋白原与前白蛋白比值(FPR)在接受经动脉化疗栓塞术(TACE)和射频消融术(RFA)治疗的巴塞罗那临床肝癌(BCLC)A - C期肝细胞癌(HCC)患者中的预后作用。
本研究纳入了2011年5月至2018年11月期间在北京首都医科大学附属北京地坛医院接受TACE和RFA治疗的240例BCLC A - C期患者。
结果显示,肿瘤大小、血管侵犯、甲胎蛋白、肝硬化、中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)以及血小板与淋巴细胞比值(PLR)在预测5年总生存期(OS)方面具有预后价值。此外,FPR(95%置信区间:1.006 - 1.013,风险比:1.009)是预测HCC患者5年OS的一个预后因素。
我们的研究表明,FPR是RFA和TACE治疗后BCLC A - C期肝细胞癌患者的一个潜在指标。