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循环FPR在BCLC A-C期肝细胞癌患者术前的预后作用：一项回顾性队列研究

The Prognostic Role of Circulating FPR Before Operation in Patients with BCLC A-C Hepatocellular Carcinoma: A Retrospective Cohort Study.

作者信息

Shen Yanjun, Xu Yawen, Wei Jianying, Li Wendong

机构信息

Department of Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.

出版信息

J Hepatocell Carcinoma. 2022 May 31;9:467-476. doi: 10.2147/JHC.S369168. eCollection 2022.

DOI:10.2147/JHC.S369168
PMID:35669908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9167061/
Abstract

BACKGROUND

This research aimed to comprehensively assess the prognostic role of fibrinogen to prealbumin ratio (FPR) in BCLC A-C HCC patients treated by TACE and RFA.

METHODS

The research included 240 patients at stage BCLC A-C treated by TACE and RFA at Beijing Ditan Hospital of Capital Medical University from May 2011 to November 2018.

RESULTS

The results showed that the size of the tumor, vascular invasion, α-foetoprotein, cirrhosis, NLR, LMR, and PLR showed prognostic value in predicting 5-year OS. Besides, FPR (95% confidence interval: 1.006-1.013, hazard ratio: 1.009) was a prognostic factor for the prediction of 5-year OS in HCC.

CONCLUSION

Our research indicated that FPR was a potential indicator for patients with BCLC A-C hepatocellular carcinoma after treatment of RFA and TACE.

摘要

背景

本研究旨在全面评估纤维蛋白原与前白蛋白比值（FPR）在接受经动脉化疗栓塞术（TACE）和射频消融术（RFA）治疗的巴塞罗那临床肝癌（BCLC）A - C期肝细胞癌（HCC）患者中的预后作用。

方法

本研究纳入了2011年5月至2018年11月期间在北京首都医科大学附属北京地坛医院接受TACE和RFA治疗的240例BCLC A - C期患者。

结果

结果显示，肿瘤大小、血管侵犯、甲胎蛋白、肝硬化、中性粒细胞与淋巴细胞比值（NLR）、淋巴细胞与单核细胞比值（LMR）以及血小板与淋巴细胞比值（PLR）在预测5年总生存期（OS）方面具有预后价值。此外，FPR（95%置信区间：1.006 - 1.013，风险比：1.009）是预测HCC患者5年OS的一个预后因素。

结论

我们的研究表明，FPR是RFA和TACE治疗后BCLC A - C期肝细胞癌患者的一个潜在指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/5e3a7c73bad6/JHC-9-467-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/3d24d0e6ff77/JHC-9-467-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/3c6a5506dcc9/JHC-9-467-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/c0c3f21e421d/JHC-9-467-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/5e3a7c73bad6/JHC-9-467-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/3d24d0e6ff77/JHC-9-467-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/3c6a5506dcc9/JHC-9-467-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/c0c3f21e421d/JHC-9-467-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ebd/9167061/5e3a7c73bad6/JHC-9-467-g0004.jpg

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1
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BMC Cancer. 2022 Jan 21;22(1):92. doi: 10.1186/s12885-022-09204-0.
2
The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis.纤维蛋白原与前白蛋白比值在消化系统恶性肿瘤中的预后价值：一项系统评价与Meta分析
Cancer Cell Int. 2022 Jan 15;22(1):22. doi: 10.1186/s12935-022-02445-w.
3
Preoperative Pre-albumin Concentration as a Predictor of Short-term Outcomes in Elderly Patients With Colorectal Cancer.
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Front Oncol. 2023 Apr 14;13:1134933. doi: 10.3389/fonc.2023.1134933. eCollection 2023.
术前前白蛋白浓度可预测老年结直肠癌患者的短期预后。
Anticancer Res. 2021 Oct;41(10):5195-5202. doi: 10.21873/anticanres.15338.
4
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JSLS. 2021 Jul-Sep;25(3). doi: 10.4293/JSLS.2021.00043.
5
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Cancer Cell Int. 2020 Mar 12;20:77. doi: 10.1186/s12935-020-1161-y. eCollection 2020.
10
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Liver Int. 2020 Apr;40(4):968-976. doi: 10.1111/liv.14405. Epub 2020 Mar 1.