Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
Nat Cardiovasc Res. 2022 Jan;1(1):59-66. doi: 10.1038/s44161-021-00005-5. Epub 2022 Jan 12.
Heart failure with preserved ejection fraction (HFpEF) is a common disorder with few effective treatments. There is currently no evidence-based method to identify preclinical HFpEF. The HFPEF score is a validated instrument to identify patients with overt HFpEF. Here we show the HFPEF score can identify individuals with preclinical HFpEF. Among individuals where heart failure was excluded (n=160), increasing HFPEF score was shown to be associated with greater left atrial dilation, left ventricular hypertrophy, and more severe diastolic dysfunction. Patients with increasing HFPEF score displayed higher pulmonary artery pressures, higher left heart filling pressures, lower cardiac index, and more severely impaired aerobic capacity during exercise. In summary, we show that among adults without heart failure, higher HFPEF score is associated with subclinical abnormalities that resemble those observed in HFpEF. These findings broaden the external validity of the HFPEF score and suggest that this instrument may help identify patients positioned to benefit from preventive interventions.
射血分数保留的心力衰竭（HFpEF）是一种常见疾病，目前治疗方法有限。目前尚无基于证据的方法来识别临床前 HFpEF。HFPEF 评分是一种已验证的工具，可用于识别有明显 HFpEF 的患者。在这里，我们表明 HFPEF 评分可以识别有临床前 HFpEF 的个体。在排除心力衰竭的个体中（n=160），HFPEF 评分的增加与左心房扩张、左心室肥厚和更严重的舒张功能障碍相关。HFPEF 评分增加的患者在运动期间显示出更高的肺动脉压、更高的左心充盈压、更低的心输出量和更严重的有氧能力受损。总之，我们表明在没有心力衰竭的成年人中，更高的 HFPEF 评分与类似 HFpEF 中观察到的亚临床异常相关。这些发现拓宽了 HFPEF 评分的外部有效性，并表明该工具可能有助于识别有受益于预防干预的患者。
