吲哚美辛在老年受试者中的药代动力学特征。
Pharmacokinetic profile of indoprofen in elderly subjects.
作者信息
Lund B, Egsmose C, Knudsen O, Andersen R B
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):721-4. doi: 10.1111/j.1365-2125.1986.tb02964.x.
Abstract
Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.
摘要
对8名老年受试者每日4次、连续7天服用半衰期较短（t1/2）的非甾体抗炎药布洛芬200毫克，结果显示出现了药物蓄积。这表明其半衰期（11小时）比年轻人中报道的半衰期（3小时）长得多。对于患骨关节炎的老年患者，建议与年轻受试者相比减少用药剂量。
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