年龄和性别对人体药物代谢的影响。
Effect of age and sex on human drug metabolism.
作者信息
O'Malley K, Crooks J, Duke E, Stevenson I H
出版信息
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
Abstract
The capacity of inpatients in a geriatric hospital to metabolize drugs was measured. The mean plasma half-life values with antipyrine and with phenylbutazone were found to be 45% and 29% greater respectively in patients than in young controls. When women alone were considered the half-life of antipyrine was 78% longer in the elderly group. In a number of elderly individuals the rate of metabolism of these two drugs was found to be extremely slow. This decreased ability to metabolize drugs may contribute to the known high incidence of adverse drug reactions in the elderly.Within the control group a significant sex difference in the rate of antipyrine metabolism was found, the mean half-life being 30% longer in the males. It is clear from these results that the age and sex of subjects must be taken into account in studies of human drug metabolism.
摘要
对一家老年医院住院患者的药物代谢能力进行了测定。结果发现，使用安替比林和保泰松时，患者血浆平均半衰期值分别比年轻对照组高45%和29%。单独考虑女性时，老年组安替比林的半衰期长78%。在一些老年人中，发现这两种药物的代谢速率极慢。这种药物代谢能力的下降可能是老年人中已知的药物不良反应高发的原因之一。在对照组中，发现安替比林代谢速率存在显著的性别差异，男性的平均半衰期长30%。从这些结果可以清楚地看出，在人体药物代谢研究中必须考虑受试者的年龄和性别。
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