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Concentrations and kinetics of carbamazepine in whole saliva, parotid saliva, serum ultrafiltrate, and serum.
Clin Pharmacol Ther. 1980 Nov;28(5):695-702. doi: 10.1038/clpt.1980.223.
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Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11-epoxide in epileptic patients.癫痫患者中卡马西平和卡马西平10,11 - 环氧化物的唾液浓度及血浆蛋白结合情况。
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Saliva carbamazepine levels in children before and during multiple dosing.多次给药前后儿童唾液中卡马西平的水平。
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Psychomotor function and psychoactive drugs.精神运动功能与精神活性药物。
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Value of saliva samples in monitoring carbamazepine concentrations in epileptic patients.
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Drug disposition in the elderly: a review of the critical factors.老年人的药物处置：关键因素综述
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Distribution and elimination kinetics of carbamazepine in man.卡马西平在人体内的分布与消除动力学
Eur J Clin Pharmacol. 1975 Feb 28;8(2):91-6. doi: 10.1007/BF00561556.
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年龄对卡马西平药代动力学及不良反应的影响。

The effects of age on carbamazepine pharmacokinetics and adverse effects.

作者信息

Hockings N, Pall A, Moody J, Davidson A V, Davidson D L

出版信息

Br J Clin Pharmacol. 1986 Dec;22(6):725-8. doi: 10.1111/j.1365-2125.1986.tb02965.x.

DOI:10.1111/j.1365-2125.1986.tb02965.x
PMID:3567018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1401196/
Abstract

The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.

摘要

在一组6名年龄在20至25岁之间的年轻志愿者和另一组5名年龄在66至84岁之间的老年志愿者中，比较了单次口服卡马西平（400毫克）的药代动力学和效果。未检测到唾液或血浆药代动力学或精神运动功能方面与年龄相关的变化。