年龄对卡马西平药代动力学及不良反应的影响。
The effects of age on carbamazepine pharmacokinetics and adverse effects.
作者信息
Hockings N, Pall A, Moody J, Davidson A V, Davidson D L
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):725-8. doi: 10.1111/j.1365-2125.1986.tb02965.x.
Abstract
The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.
摘要
在一组6名年龄在20至25岁之间的年轻志愿者和另一组5名年龄在66至84岁之间的老年志愿者中，比较了单次口服卡马西平（400毫克）的药代动力学和效果。未检测到唾液或血浆药代动力学或精神运动功能方面与年龄相关的变化。
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本文引用的文献
1
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2
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Br J Clin Pharmacol. 1981 Jul;12(1):31-7. doi: 10.1111/j.1365-2125.1981.tb01851.x.
3
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4
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