Schmucker D L
J Am Geriatr Soc. 1984 Feb;32(2):144-9. doi: 10.1111/j.1532-5415.1984.tb05856.x.
There are meaningful direct correlations between increasing patient age, the incidence of multiple pathologic conditions, and the implementation of polypharmacy regimens. The latter practice culminates in a significant increase in the incidence of adverse drug reactions in these patients. However, the reason the elderly often respond less favorably to many drugs in comparison with young or mature subjects remains unresolved, although the literature is replete with clinical studies that document this phenomenon. This paper presents the state of our knowledge to date.
患者年龄增加、多种病理状况的发生率以及多药联合治疗方案的实施之间存在有意义的直接关联。后一种做法最终导致这些患者药物不良反应的发生率显著增加。然而，尽管文献中有大量临床研究记录了这一现象，但与年轻或成熟个体相比，老年人对许多药物的反应往往较差的原因仍未得到解决。本文介绍了我们目前所掌握的知识状况。
