氯喹、氨苯砜和乙胺嘧啶在人乳中的排泄情况。
Excretion of chloroquine, dapsone and pyrimethamine in human milk.
作者信息
Edstein M D, Veenendaal J R, Newman K, Hyslop R
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):733-5. doi: 10.1111/j.1365-2125.1986.tb02967.x.
Abstract
The concentration of chloroquine (CQ), dapsone (DDS) and pyrimethamine (PYR) in plasma and milk were measured following the coadministration of a single dose of chloroquine and Maloprim to lactating women. The milk to plasma area under the concentration-time curve (AUC) ratio ranged from 1.96 to 4.26 for CQ, 0.22 to 0.45 for DDS and 0.46 to 0.66 for PYR. Assuming a daily milk ingestion of 1 l by the infant, the maximum percentage of the maternal dose for CQ, DDS and PYR in milk was 4.2%, 14.3% and 45.6%, respectively, over a 9 day period.
摘要
在向哺乳期妇女联合单次给予氯喹和复方磺胺多辛后，测定了她们血浆和乳汁中氯喹（CQ）、氨苯砜（DDS）和乙胺嘧啶（PYR）的浓度。CQ的乳汁与血浆浓度-时间曲线下面积（AUC）比值在1.96至4.26之间，DDS为0.22至0.45，PYR为0.46至0.66。假设婴儿每日摄入1升乳汁，在9天时间里，乳汁中CQ、DDS和PYR的母体剂量最大百分比分别为4.2%、14.3%和45.6%。
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