重症监护病房中通过透析治疗成功治愈的伴有极高血乳酸水平的利奈唑胺中毒：一例报告
Linezolid Intoxication with Extreme Lactate Blood Levels Successfully Treated with Dialytic Treatment in ICU: A Case Report.
作者信息
Schiavoni Lorenzo, Mattei Alessia, Pascarella Giuseppe, Strumia Alessandro, Nenna Antonio, Chello Massimo, Agrò Felice E
机构信息
Department of Medicine, Unit of Anaesthesia, Intensive Care and Pain Management, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
Department of Medicine, Unit of Cardiac Surgery, Campus Bio-Medico di Roma University, via Álvaro del Portillo 21, 00128 Rome, Italy.
出版信息
Recent Adv Inflamm Allergy Drug Discov. 2022;16(1):50-53. doi: 10.2174/2772270816666220606111049.
INTRODUCTION
Lactic acidosis is a rare but life-threatening complication associated with prolonged linezolid therapy. No specific treatment is suggested, except for antibiotic therapy interruption.
CASE REPORT
A 70-years-old woman faced severe linezolid intoxication after antibiotics therapy initiation for infection of a surgical sternal wound. The patient suffered from a severe increment of blood lactate and thrombocytopenia. She was admitted to ICU twice, and due to dialytic treatment, linezolid and lactate serum levels came back to normality.
CONCLUSION
More studies should be conducted to evaluate the human tissue storage sites of linezolid and the influence of various factors on its clearance and plasma concentrations in critically ill patients.
引言
乳酸酸中毒是与长期使用利奈唑胺治疗相关的一种罕见但危及生命的并发症。除中断抗生素治疗外，尚无具体治疗建议。
病例报告
一名70岁女性在开始使用抗生素治疗手术胸骨伤口感染后出现严重的利奈唑胺中毒。患者出现血乳酸严重升高和血小板减少。她两次入住重症监护病房，由于透析治疗，利奈唑胺和乳酸血清水平恢复正常。
结论
应开展更多研究，以评估利奈唑胺在人体组织中的储存部位以及各种因素对危重症患者其清除率和血浆浓度的影响。
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