雷尼替丁和西咪替丁；与单次剂量及稳态硝苯地平给药的药物相互作用。
Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration.
作者信息
Smith S R, Kendall M J, Lobo J, Beerahee A, Jack D B, Wilkins M R
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):311-5. doi: 10.1111/j.1365-2125.1987.tb03050.x.
Abstract
The effect of ranitidine 300 mg once daily and cimetidine 800 mg once daily on the disposition of nifedipine was studied in two groups of 12 volunteers. Both investigations were placebo-controlled cross-over studies. The first group received ranitidine, cimetidine or placebo for 5 days with 20 mg nifedipine given on the 5th day. Each period was separated by 1 week. The second group received nifedipine 10 mg three times daily for 5 days together with the H2-receptor antagonist or placebo. Cimetidine produced a significant increase in the AUC of both single and steady state dosing of nifedipine. Peak nifedipine levels were significantly increased only in the chronic dose study compared to placebo. Ranitidine did not produce any significant changes in either study.
摘要
在两组各12名志愿者中研究了每日一次服用300毫克雷尼替丁和每日一次服用800毫克西咪替丁对硝苯地平处置的影响。两项研究均为安慰剂对照的交叉研究。第一组接受雷尼替丁、西咪替丁或安慰剂治疗5天，在第5天给予20毫克硝苯地平。每个周期间隔1周。第二组每日三次服用10毫克硝苯地平，共5天，同时服用H2受体拮抗剂或安慰剂。西咪替丁使硝苯地平单次给药和稳态给药的AUC均显著增加。与安慰剂相比，仅在慢性剂量研究中硝苯地平的峰值水平显著升高。在两项研究中雷尼替丁均未产生任何显著变化。
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本文引用的文献
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