雷尼替丁和西咪替丁；与单次剂量及稳态硝苯地平给药的药物相互作用。
Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration.
作者信息
Smith S R, Kendall M J, Lobo J, Beerahee A, Jack D B, Wilkins M R
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):311-5. doi: 10.1111/j.1365-2125.1987.tb03050.x.
Abstract
The effect of ranitidine 300 mg once daily and cimetidine 800 mg once daily on the disposition of nifedipine was studied in two groups of 12 volunteers. Both investigations were placebo-controlled cross-over studies. The first group received ranitidine, cimetidine or placebo for 5 days with 20 mg nifedipine given on the 5th day. Each period was separated by 1 week. The second group received nifedipine 10 mg three times daily for 5 days together with the H2-receptor antagonist or placebo. Cimetidine produced a significant increase in the AUC of both single and steady state dosing of nifedipine. Peak nifedipine levels were significantly increased only in the chronic dose study compared to placebo. Ranitidine did not produce any significant changes in either study.
摘要
在两组各12名志愿者中研究了每日一次服用300毫克雷尼替丁和每日一次服用800毫克西咪替丁对硝苯地平处置的影响。两项研究均为安慰剂对照的交叉研究。第一组接受雷尼替丁、西咪替丁或安慰剂治疗5天，在第5天给予20毫克硝苯地平。每个周期间隔1周。第二组每日三次服用10毫克硝苯地平，共5天，同时服用H2受体拮抗剂或安慰剂。西咪替丁使硝苯地平单次给药和稳态给药的AUC均显著增加。与安慰剂相比，仅在慢性剂量研究中硝苯地平的峰值水平显著升高。在两项研究中雷尼替丁均未产生任何显著变化。
相似文献
1
Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration.雷尼替丁和西咪替丁；与单次剂量及稳态硝苯地平给药的药物相互作用。
Br J Clin Pharmacol. 1987 Mar;23(3):311-5. doi: 10.1111/j.1365-2125.1987.tb03050.x.
2
The pharmacokinetics and pharmacodynamics of nifedipine at steady state during concomitant administration of cimetidine or high dose ranitidine.西咪替丁或高剂量雷尼替丁联合给药时硝苯地平稳态下的药代动力学和药效学。
Br J Clin Pharmacol. 1991 Oct;32(4):519-22. doi: 10.1111/j.1365-2125.1991.tb03943.x.
3
The influence of two histamine H2-receptor antagonists, cimetidine and ranitidine, on the plasma levels and clinical effect of nifedipine and metoprolol.
Arch Toxicol Suppl. 1984;7:256-9. doi: 10.1007/978-3-642-69132-4_38.
4
[Effect of cimetidine and ranitidine on the pharmacokinetics and anti-hypertensive effect of nifedipine].
Dtsch Med Wochenschr. 1983 Nov 18;108(46):1757-61. doi: 10.1055/s-2008-1069821.
5
Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics.西咪替丁或雷尼替丁给药对硝苯地平药代动力学和药效学的影响。
Clin Pharmacol Ther. 1988 Jun;43(6):673-80. doi: 10.1038/clpt.1988.94.
6
Effect of single doses of cimetidine and ranitidine on the steady-state plasma levels of midazolam.西咪替丁和雷尼替丁单次剂量对咪达唑仑稳态血药浓度的影响。
Clin Pharmacol Ther. 1985 Dec;38(6):652-5. doi: 10.1038/clpt.1985.240.
7
Interaction of ibuprofen with the H-2 receptor antagonists ranitidine and cimetidine.
Clin Pharmacol Ther. 1985 Dec;38(6):648-51. doi: 10.1038/clpt.1985.239.
8
The influence of cimetidine versus ranitidine on doxepin pharmacokinetics.
Eur J Clin Pharmacol. 1987;32(2):159-64. doi: 10.1007/BF00542189.
9
Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide.西咪替丁和雷尼替丁对单剂量多非利特药代动力学和药效学的影响。
Br J Clin Pharmacol. 2000 Jan;49(1):64-71. doi: 10.1046/j.1365-2125.2000.00114.x.
10
The effects of cimetidine and ranitidine on the pharmacokinetics of cifenline.西咪替丁和雷尼替丁对西芬宁药代动力学的影响。
Br J Clin Pharmacol. 1991 Apr;31(4):481-3. doi: 10.1111/j.1365-2125.1991.tb05566.x.
引用本文的文献
1
Clinical Trial Data-Driven Risk Assessment of Drug-Drug Interactions: A Rapid and Accurate Decision-Making Tool.临床试验数据驱动的药物相互作用风险评估：一种快速准确的决策工具。
Clin Pharmacokinet. 2024 Aug;63(8):1147-1165. doi: 10.1007/s40262-024-01404-0. Epub 2024 Aug 5.
2
Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use.虚拟临床试验指导硝苯地平儿科适用剂型及给药策略的设计，以适配不同年龄段儿童。
Pharmaceutics. 2023 Feb 7;15(2):556. doi: 10.3390/pharmaceutics15020556.
3
Drug Interactions Associated With Therapies for Pulmonary Arterial Hypertension.与肺动脉高压治疗相关的药物相互作用
J Pharm Technol. 2022 Dec;38(6):349-359. doi: 10.1177/87551225221114001. Epub 2022 Aug 8.
4
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.用于预测经多种酶途径代谢的药物在孕妇体内药代动力学的基于生理的药代动力学模型。
Clin Pharmacokinet. 2018 Jun;57(6):749-768. doi: 10.1007/s40262-017-0594-5.
5
A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction.用于预测 CYP3A 代谢药物在孕妇体内处置的 PBPK 模型：验证和辨别 CYP3A 诱导的部位。
CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1(9):e3. doi: 10.1038/psp.2012.2.
6
Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine.西咪替丁和雷尼替丁联合给药对特非那定药代动力学及心电图影响的研究
Eur J Clin Pharmacol. 1993;45(1):41-6. doi: 10.1007/BF00315348.
7
Calcium antagonists. Drug interactions of clinical significance.钙拮抗剂。具有临床意义的药物相互作用。
Drug Saf. 1995 Sep;13(3):157-87. doi: 10.2165/00002018-199513030-00003.
8
Calcium channel antagonists. Part IV: Side effects and contraindications drug interactions and combinations.钙通道拮抗剂。第四部分：副作用、禁忌、药物相互作用及联合用药
Cardiovasc Drugs Ther. 1988 Jul;2(2):177-89. doi: 10.1007/BF00051233.
9
Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactions.雷尼替丁与西咪替丁。二者引发具有临床重要性药物相互作用可能性的比较。
Clin Pharmacokinet. 1988 Jul;15(1):44-56. doi: 10.2165/00003088-198815010-00004.
10
Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.雷尼替丁。对其药效学、药代动力学特性以及在消化性溃疡疾病和其他相关疾病中的治疗应用的最新综述。
Drugs. 1989 Jun;37(6):801-70. doi: 10.2165/00003495-198937060-00003.
本文引用的文献
1
The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat.西咪替丁对大鼠体内外微粒体药物代谢的影响。
Biochem Pharmacol. 1980 Nov 15;29(22):3075-80. doi: 10.1016/0006-2952(80)90448-7.
2
Effect of cimetidine on microsomal drug metabolism in man.西咪替丁对人体微粒体药物代谢的影响。
Eur J Clin Pharmacol. 1980 Aug;18(2):185-7. doi: 10.1007/BF00561588.
3
Cytochrome P-450 and ethoxycoumarin-deethylation in rat gastric microsomes: induction by 3-methylcholanthrene and inhibition by cimetidine.
Biochem Biophys Res Commun. 1981 Sep 30;102(2):784-90. doi: 10.1016/s0006-291x(81)80200-8.
4
Inhibition of drug metabolism by cimetidine in man: dependence on pretreatment microsomal liver function.西咪替丁对人体药物代谢的抑制作用：取决于预处理的微粒体肝功能。
Eur J Clin Invest. 1982 Oct;12(5):429-32. doi: 10.1111/j.1365-2362.1982.tb00691.x.
5
Determination of nifedipine in human plasma by capillary gas chromatography with nitrogen detection.采用带氮检测的毛细管气相色谱法测定人血浆中的硝苯地平。
J Chromatogr. 1983 Nov 25;279:675-80. doi: 10.1016/s0021-9673(01)93672-6.
6
Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man.
Biochem Pharmacol. 1984 Nov 15;33(22):3721-4. doi: 10.1016/0006-2952(84)90165-5.
7
[Effect of cimetidine and ranitidine on the pharmacokinetics and anti-hypertensive effect of nifedipine].
Dtsch Med Wochenschr. 1983 Nov 18;108(46):1757-61. doi: 10.1055/s-2008-1069821.
8
Histamine H2-antagonist drug interactions in perspective: mechanistic concepts and clinical implications.组胺H2拮抗剂药物相互作用的展望：作用机制及临床意义
Am J Med. 1984 Nov 19;77(5B):57-84.
9
Cimetidine--benzodiazepine interactions.
Am J Hosp Pharm. 1982 Feb;39(2):236, 242.
10
Interaction of H2-receptor antagonists with drug-metabolizing enzymes.
Biochem Soc Trans. 1981 Feb;9(1):113-4. doi: 10.1042/bst0090113.
Zotero 插件