Seideman P, Sollevi A, Fredholm B B
Br J Clin Pharmacol. 1987 Mar;23(3):323-30. doi: 10.1111/j.1365-2125.1987.tb03052.x.
The effect of dipyridamole alone and in combination with indomethacin was studied in 11 water loaded rheumatic patients with normal kidney function. The adenosine uptake inhibitor dipyridamole and the prostaglandin synthesis inhibitor indomethacin decreased diuresis by 25-50% when given alone and by approximately 80% when combined. These effects were not associated with changes in renal PAH-clearance, but may be partially related to a fall in GFR. Sodium excretion was decreased in parallel with the fall in GFR. In addition, both indomethacin and dipyridamole reduced the free water clearance. Theophylline at therapeutic plasma levels reversed the reduction in GFR and transiently counteracted the inhibition of tubular water and sodium excretion induced by combined dipyridamole and indomethacin treatment. The results suggest that endogenous adenosine and prostaglandins are both involved in the control of renal function in man, and that drugs that affect these two autocoids may interact to cause adverse effects in man.
在11名肾功能正常且水负荷的风湿性疾病患者中，研究了双嘧达莫单独使用及其与吲哚美辛联合使用的效果。腺苷摄取抑制剂双嘧达莫和前列腺素合成抑制剂吲哚美辛单独使用时可使尿量减少25% - 50%，联合使用时可使尿量减少约80%。这些作用与肾对对氨基马尿酸清除率的变化无关，但可能部分与肾小球滤过率（GFR）下降有关。钠排泄量与GFR下降平行减少。此外，吲哚美辛和双嘧达莫均降低了自由水清除率。治疗血浆浓度的茶碱可逆转GFR的降低，并短暂抵消双嘧达莫与吲哚美辛联合治疗所致的肾小管水和钠排泄抑制。结果表明，内源性腺苷和前列腺素均参与人体肾功能的调控，影响这两种自体活性物质的药物可能相互作用，对人体产生不良反应。
