School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Org Lett. 2022 Jun 17;24(23):4187-4191. doi: 10.1021/acs.orglett.2c01468. Epub 2022 Jun 7.
The construction of 2-amino-1,3-selenazole skeleton was realized via the PhICl/KSeCN-enabled electrophilic selenocyanation of β-enaminones and β-enamino esters followed by intramolecular cyclization under basic conditions. Compared to the classical Hantzsch strategy that utilizes selenourea or its analogues as starting materials or crucial intermediates, this method might represent an alternative approach for the assembly of 1,3-selenazole framework through a different pathway.
通过 PhICl/KSeCN 促进的β-烯胺酮和β-烯氨基酯的亲电硒氰化反应，然后在碱性条件下进行分子内环化，实现了 2-氨基-1,3-硒唑骨架的构建。与经典的 Hantzsch 策略（利用硒脲或其类似物作为起始原料或关键中间体）相比，这种方法可能代表了通过不同途径构建 1,3-硒唑骨架的替代方法。
