1,3-硒唑的设计、合成及生物活性研究的最新进展

Recent Advances in Design, Synthesis, and Biological Activity Studies of 1,3-Selenazoles.

作者信息

Makhaeva Nataliya A, Amosova Svetlana V, Filippov Andrey S, Potapov Vladimir A, Musalov Maxim V

机构信息

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia.

出版信息

Biomolecules. 2024 Dec 2;14(12):1546. doi: 10.3390/biom14121546.

DOI:10.3390/biom14121546

PMID:39766253

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674745/

Abstract

The review examines recent advances in the design and synthesis of 1,3-selenazole derivatives since 2000. Various synthetic approaches to 1,3-selenazoles and reaction conditions are discussed. The beneficial properties of 1,3-selenazoles, especially their biological activity, are emphasized. Compounds with antitumor, antiviral (HIV-1 and HIV-2), antibacterial, antifungal, antiproliferative, anticonvulsant, and antioxidant activity are highlighted.

摘要

本综述考察了自2000年以来1,3-硒唑衍生物设计与合成方面的最新进展。讨论了合成1,3-硒唑的各种方法及反应条件。强调了1,3-硒唑的有益特性，尤其是它们的生物活性。重点介绍了具有抗肿瘤、抗病毒（HIV-1和HIV-2）、抗菌、抗真菌、抗增殖、抗惊厥和抗氧化活性的化合物。