School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
J Mol Endocrinol. 2022 Oct 11;69(4):T51-T57. doi: 10.1530/JME-22-0067. Print 2022 Nov 1.
Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the mammalian male. This is possible because of an active stem cell pool and an ordered entry into the germ cell developmental sequence. The ordered entry is a result of the synthesis and action of retinoic acid allowing for the onset of spermatogonial differentiation and an irreversible commitment to spermatogenesis. The periodic appearance and actions of retinoic acid along the seminiferous tubules is a result of the interactions between germ cells and Sertoli cells that result in the generation and maintenance of the cycle of the seminiferous epithelium and is the subject of this review.
精子发生是一个高度组织化和受调控的过程，需要雄性哺乳动物在其生殖寿命内不断产生数百万个配子。这是因为存在一个活跃的干细胞池，并有序地进入生殖细胞发育序列。有序进入是由于视黄酸的合成和作用，从而允许精原细胞分化，并不可逆地承诺进行精子发生。视黄酸沿着生精小管周期性出现并发挥作用，这是由于生殖细胞和支持细胞之间的相互作用的结果，导致生精上皮周期的产生和维持，这是本综述的主题。
