School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, India.
Homi Bhabha National Institute, Mumbai, India.
J Membr Biol. 2022 Dec;255(6):705-722. doi: 10.1007/s00232-022-00245-x. Epub 2022 Jun 7.
Membrane interfaces are vital for various cellular processes, and their involvement in neurodegenerative disorders such as Alzheimer's and Parkinson's disease has taken precedence in recent years. The amyloidogenic proteins associated with neurodegenerative diseases interact with the neuronal membrane through various means, which has implications for both the onset and progression of the disease. The parameters that regulate the interaction between the membrane and the amyloids remain poorly understood. The review focuses on the various aspects of membrane interactions of amyloids, particularly amyloid-β (Aβ) peptides and Tau involved in Alzheimer's and α-synuclein involved in Parkinson's disease. The genetic, cell biological, biochemical, and biophysical studies that form the basis for our current understanding of the membrane interactions of Aβ peptides, Tau, and α-synuclein are discussed.
膜界面对于各种细胞过程至关重要，近年来，它们在阿尔茨海默病和帕金森病等神经退行性疾病中的作用已成为研究重点。与神经退行性疾病相关的淀粉样蛋白通过各种方式与神经元膜相互作用，这对疾病的发生和进展都有影响。调节膜与淀粉样蛋白相互作用的参数仍知之甚少。本综述重点讨论了淀粉样蛋白的各种膜相互作用方面，特别是与阿尔茨海默病相关的淀粉样β（Aβ）肽和 Tau，以及与帕金森病相关的α-突触核蛋白。讨论了构成我们目前对 Aβ肽、Tau 和 α-突触核蛋白与膜相互作用的理解的遗传、细胞生物学、生物化学和生物物理研究。
