Sandvei P, Nordhagen R, Michaelsen T E, Wolthuis K
Br J Haematol. 1987 Mar;65(3):357-9. doi: 10.1111/j.1365-2141.1987.tb06868.x.
A female patient on Fluorouracil (5-FU) therapy for rectal carcinoma developed acute intravascular haemolysis with her fifteenth drug injection; a similar episode occurred later after a controlled challenge with the drug. A 5-FU-dependent complement-activating IgM antibody, which reacted with RBC in an indirect antiglobulin test, was detected in her serum. The antibody did not react with cord RBC, but a blood group specificity could not be determined. An excess of 5-FU in the indirect antiglobulin tests resulted in inhibition of these reactions.
一名接受氟尿嘧啶（5-FU）治疗直肠癌的女性患者在第15次注射药物时发生急性血管内溶血；在对该药物进行对照激发试验后，随后又发生了类似事件。在她的血清中检测到一种依赖5-FU的补体激活IgM抗体，该抗体在间接抗球蛋白试验中与红细胞发生反应。该抗体与脐血红细胞不发生反应，但无法确定血型特异性。间接抗球蛋白试验中过量的5-FU导致这些反应受到抑制。
